Results 151 to 160 of about 75,567 (173)

Isolation and genomic characterization of Psychrobacillus isolate L3 and bacteriophage Spoks: a new phage-host pair from Antarctic soil. [PDF]

BMC Genomics
Zrelovs N, Svanberga K, Jansons J, Lamsters K, Karuss J, Krievans M, Fridmanis D, Dislers A, Kazaks A.   +8 more
europepmc   +1 more source

Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations. [PDF]

Microbiol Spectr
Demirdjian S, Duong VN, Byrum JN, Nayak A, McKinney CB, Perry JK, Callebaut C, Rodgers KK, Falkard B, Feng JY.   +9 more
europepmc   +1 more source

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Will Integrase Inhibitors be Used as Microbicides?

Current HIV Research, 2012
Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections including HIV-1. Despite more than two decades of HIV-1 research, there is still no efficacious HIV-1 vaccine, and the scientific community appears ...
CUZZUCOLI CRUCITTI, GIULIANA, Maurizio Botta, DI SANTO, Roberto   +2 more
openaire   +4 more sources

The clinical pharmacology of integrase inhibitors

Expert Review of Clinical Pharmacology, 2018
Introduction: Treatment of HIV infection has consistently evolved in the last three decades. A steady improvement in efficacy tolerability, safety, and practical aspects of treatment intake has made HIV infection much easier to manage over the long term, and in optimal treatment conditions the life expectancy of persons living with HIV infection now ...
Di Perri, Giovanni, Calcagno, Andrea, Trentalange, Alice, Bonora, Stefano   +3 more
openaire   +2 more sources

Oligomerization of Retrovirus Integrases

2018
Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric 'intasome' complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of ...
Duane P. Grandgenett, Hideki Aihara
openaire   +3 more sources

Novel integrase inhibitors for HIV

Expert Opinion on Investigational Drugs, 2010
Integrase inhibitors are the newest class of antiretroviral agents developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) currently approved for the treatment of HIV-infected patients, has proven to be a potent and well-tolerated antiretroviral (ARV) agent.
Martin Markowitz, Nicole Prada
openaire   +3 more sources

Tolerability of HIV integrase inhibitors

Current Opinion in HIV and AIDS, 2012
This review discusses the available safety data for three integrase strand transfer inhibitors (INSTIs)--raltegravir, elvitegravir and dolutegravir--derived from studies in both HIV-infected and HIV-uninfected cohorts.Phase 2 and 3 clinical trials show that all three INSTIs are well tolerated in treatment-naive and treatment-experienced patients with ...
Frederick J. Lee, Andrew Carr
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Substrate Recognition by Retroviral Integrases

1999
Substrate recognition by the retroviral IN enzyme is critical for retroviral integration. To catalyze this recombination event, IN must recognize and act on two types of substrates, viral DNA and host DNA, yet the necessary interactions exhibit markedly different degrees of specificity.
Richard A. Katz, Michael Katzman
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Phage Integrases: Biology and Applications

Journal of Molecular Biology, 2004
Phage integrases are enzymes that mediate unidirectional site-specific recombination between two DNA recognition sequences, the phage attachment site, attP, and the bacterial attachment site, attB. Integrases may be grouped into two major families, the tyrosine recombinases and the serine recombinases, based on their mode of catalysis.
Amy C. Groth, Michele P. Calos
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Zinc binding by retroviral integrase

Biochemical and Biophysical Research Communications, 1992
Zinc binding by integrase from Moloney murine leukaemia virus and a protein A fusion protein containing integrase from human immunodeficiency virus type 1 was demonstrated by a zinc blotting technique using 65ZnCl2. Autoradiography revealed a clear band that was absent from the appropriate controls.
D.W. Hough, A.J. Wolstenholme, B. Edwards, A.R. McEuen, M.J. Danson, K.A. Koepke, A.E. Ball, B.A. Jennings   +7 more
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