The Peptide PROTAC Modality: A New Strategy for Drug Discovery
MedComm, Volume 6, Issue 4, April 2025.Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley +1 more source
The Bacteroides mobilizable insertion element, NBU1, integrates into the 3' end of a Leu-tRNA gene and has an integrase that is a member of the lambda integrase family [PDF]
, 1996 Nadja B. Shoemaker +2 more
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AURKA/PLK1/CDC25C Axis as a Novel Therapeutic Target in INI1‐Deficient Epithelioid Sarcoma
Cancer Science, Volume 116, Issue 4, Page 976-989, April 2025.This study confirmed that reintroducing INI1 in epithelioid sarcoma (EpS) markedly reduced cell proliferation, eradicated tumorigenicity, and downregulated AURKA and its downstream effectors, including PLK1 and CDC25C. Additionally, alisertib, a selective AURKA inhibitor, induced G2/M cell cycle arrest and apoptosis in EpS cells by inactivating AURKA's
Akitomo Inoue +7 more
wiley +1 more source
The core domain of retrotransposon integrase in Hordeum: predicted structure and evolution [PDF]
, 1998 A. Suoniemi +4 more
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Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders
Cell Proliferation, Volume 58, Issue 4, April 2025.This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
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Detection of an integrase gene in clinical isolates of Mycobacterium tuberculosis
International Journal of Mycobacteriology, 2015 Introduction: Drug resistance in Mycobacterium tuberculosis (MTB) is caused by many mechanisms. Integrons are genetic units characterized by their ability to capture and incorporate bacterial genomes by recombination and may contain resistance-related ...
M Arjomandzadegan +3 more
doaj
Point‐of‐care nucleic acid testing – a step forward in controlling the HIV epidemic: A review
HIV Medicine, Volume 26, Issue 4, Page 536-545, April 2025.Abstract Introduction The HIV/AIDS epidemic, with 85.6 million infections and 40.4 million AIDS‐related deaths globally, remains a critical public health challenge. Current diagnostic methods, primarily fourth‐generation immunoassays, have limitations due to their long window periods, and most viral load assays require centralized testing protocols ...
Suleyman Sarp Pinar +4 more
wiley +1 more source
Processing of deoxyuridine mismatches and abasic sites by human immunodeficiency virus type- integrase [PDF]
, 1995 Abhijit Mazumder, Yves Pommier
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A programmatic assessment of dolutegravir adverse events and discontinuations in Uganda
HIV Medicine, Volume 26, Issue 4, Page 592-605, April 2025.Abstract Introduction Dolutegravir is now extensively used in sub‐Saharan Africa as a preferred component of antiretroviral therapy (ART). There is a paucity of large studies using routinely collected data from African people living with HIV on dolutegravir‐based regimens to inform HIV programmes.
Eva Agnes Laker Odongpiny +12 more
wiley +1 more source