Results 161 to 170 of about 39,252 (190)
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1995
Abstract The linear DNA copy of the HIV genome made by reverse transcription must be integrated into a chromosome of the infected cell in order to be stably maintained and efficiently transcribed. DNA integration is therefore a necessary step in the viral replication cycle. HIV DNA is inserted into the host genome by a specialized DNA
R Craigie, A B Hickman, A Engelman
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Abstract The linear DNA copy of the HIV genome made by reverse transcription must be integrated into a chromosome of the infected cell in order to be stably maintained and efficiently transcribed. DNA integration is therefore a necessary step in the viral replication cycle. HIV DNA is inserted into the host genome by a specialized DNA
R Craigie, A B Hickman, A Engelman
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Expert Opinion on Therapeutic Targets, 2001
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
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Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
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Oligomerization of Retrovirus Integrases
2018Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric 'intasome' complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of ...
Duane P, Grandgenett, Hideki, Aihara
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Novel integrase inhibitors for HIV
Expert Opinion on Investigational Drugs, 2010Integrase inhibitors are the newest class of antiretroviral agents developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) currently approved for the treatment of HIV-infected patients, has proven to be a potent and well-tolerated antiretroviral (ARV) agent.
Nicole, Prada, Martin, Markowitz
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Substrate Recognition by Retroviral Integrases
1999Substrate recognition by the retroviral IN enzyme is critical for retroviral integration. To catalyze this recombination event, IN must recognize and act on two types of substrates, viral DNA and host DNA, yet the necessary interactions exhibit markedly different degrees of specificity.
M, Katzman, R A, Katz
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Quinoline-based HIV Integrase Inhibitors
Current Pharmaceutical Design, 2013HIV integrase became an important target for drug development more than twenty years ago. However, progress has been hampered by the lack of assays suitable for high throughput screening, a reliable crystal structure or pharmacophore. Thus, a real breakthrough was only observed in 2007 with the introduction of the first integrase inhibitor, raltegravir,
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