Results 11 to 20 of about 57,554 (268)
Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases [PDF]
Biomolecules, 2021 Integrases of different retroviruses assemble as functional complexes with varying multimers of the protein. Retroviral integrases require a divalent metal cation to perform one-step transesterification catalysis.
Anthony J. Rabe +3 more
doaj +3 more sources
Weight gain and integrase inhibitors. [PDF]
Current Opinion in Infectious Diseases, 2019 PURPOSE OF REVIEW Weight gain and obesity among people living with HIV (PLWH) is a serious problem that occurs often after initiation of antiretroviral therapy but may be worse with integrase strand transfer inhibitors (INSTIs).
A. Eckard, G. McComsey
semanticscholar +3 more sources
Structural basis of second-generation HIV integrase inhibitor action and viral resistance
Science, 2020 Strengths and weaknesses of an HIV drug Retroviruses replicate by inserting a copy of their RNA, which has been reverse transcribed into DNA, into the host genome. This process involves the intasome, a nucleoprotein complex comprising copies of the viral
N. Cook +9 more
semanticscholar +1 more source
PP2A Phosphatase as an Emerging Viral Host Factor
Frontiers in Cellular and Infection Microbiology, 2021 Protein phosphatase 2A (PP2A) is one of the most ubiquitous cellular proteins and is responsible for the vast majority of Ser/Thr phosphatase activity in eukaryotes. PP2A is a heterotrimer, and its assembly, intracellular localization, enzymatic activity,
Michal Slawomir Barski +2 more
doaj +1 more source
Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis
Viruses, 2020 The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the reverse-transcribed viral DNA into the host chromosome. This function of IN has been well studied, and the knowledge gained has informed the design of small ...
Jennifer L. Elliott, Sebla B. Kutluay
doaj +1 more source
Nature Communications, 2020 Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of second generation integrase inhibitors. We sequenced pretreatment plasma specimens from the ADVANCE trial (NCT03122262).
M. Siedner +12 more
semanticscholar +1 more source
The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function
mBio, 2023 Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an emerging class of small molecules that disrupt viral maturation by inducing the aberrant multimerization of IN. Here, we present cocrystal structures of HIV-1 IN with two potent ALLINIs, namely,
Matthew R. Singer +14 more
doaj +1 more source
Integrase and integration: biochemical activities of HIV-1 integrase [PDF]
Retrovirology, 2008 Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses integration. The process of integration can be divided into two sequential reactions.
Deprez Eric +4 more
openaire +3 more sources
HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure
Retrovirology, 2009 In a recent summary of integrase sequences, primary integrase inhibitor mutations were rare. In a review of integrase inhibitor-naïve Australian HIV-1 sequences, primary mutations were not identified, although the accessory mutation G140S was detected. A
Wang Bin +5 more
doaj +1 more source
Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins
Frontiers in Microbiology, 2022 The emergence and spread of new HIV-1 variants pose a challenge for the effectiveness of antiretrovirals (ARV) targeting Pol proteins. During viral evolution, non-synonymous mutations have fixed along the viral genome, leading to amino acid (aa) changes ...
Paloma Troyano-Hernáez +2 more
doaj +1 more source