Results 31 to 40 of about 54,271 (286)
Frontiers in Microbiology, 2022 Salmonella enterica serovar Indiana (S. Indiana) has aroused widespread concern as an important zoonotic pathogen. The molecular mechanism of multidrug resistance (MDR) in S. Indiana is not known and should be assessed.
Xuefeng Wang +6 more
doaj +1 more source
HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure
Retrovirology, 2009 In a recent summary of integrase sequences, primary integrase inhibitor mutations were rare. In a review of integrase inhibitor-naïve Australian HIV-1 sequences, primary mutations were not identified, although the accessory mutation G140S was detected. A
Wang Bin +5 more
doaj +1 more source
A New Freshwater Cyanosiphovirus Harboring Integrase [PDF]
Frontiers in Microbiology, 2018 Pelagic cyanobacteria are key players in the functioning of aquatic ecosystems, and their viruses (cyanophages) potentially affect the abundance and composition of cyanobacterial communities. Yet, there are few well-described freshwater cyanophages relative to their marine counterparts, and in general, few cyanosiphoviruses (family Siphoviridae) have ...
Kevin Xu Zhong +11 more
openaire +8 more sources
EMBO reports, 2010 Antiretroviral drugs to prevent integration of the HIV viral genome into chromosomes are undergoing clinical trials, yet they have been developed with an imperfect understanding of their mechanism of action. The recent crystal structure of the major viral protein integrase from a related, little‐known retrovirus, has finally provided insight into how ...
openaire +2 more sources
Pharmacology of HIV integrase inhibitors [PDF]
Current Opinion in HIV and AIDS, 2012 The purpose of this paper is to review recent and relevant pharmacology data for three HIV integrase inhibitors: raltegravir (marketed), dolutegravir and elvitegravir (both in Phase III drug development).
Angela D. M. Kashuba +2 more
openaire +3 more sources
Microorganisms, 2022 Shewanella spp. are Gram-negative bacteria that thrive in aquatic niches and also can cause infectious diseases as opportunistic pathogens. Chromosomal (CI) and mobile integrons (MI) were previously described in some Shewanella isolates.
Teolincacihuatl Ayala Nuñez +4 more
doaj +1 more source
Immunology &Cell Biology, Volume 101, Issue 1, Page 36-48, January 2023., 2023 Type 1 diabetes is caused by aberrant activation of autoreactive T cells specific for the islet beta cells, but how these cells evade tolerance to become effector T cells is unknown. This study investigated whether islet‐specific T cells are activated in the gut via cross‐reactive bacterial derived peptides (molecular mimicry) or by non‐specific ...
Mirei Okada +7 more
wiley +1 more source
Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes
Retrovirology, 2009 Background Integrase inhibitors are currently being incorporated into highly active antiretroviral therapy (HAART). Due to high HIV variability, integrase inhibitor efficacy must be evaluated against a range of integrase enzymes from different subtypes ...
Kuhl Björn D +7 more
doaj +1 more source
Docking Studies on HIV Integrase Inhibitors Based On Potential Ligand Binding Sites [PDF]
International Journal on Bioinformatics & Biosciences, vol. 2, pp.
21-29, 2012, 2012 HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Integrase is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell.
arxiv +1 more source
Molecular Microbiology, Volume 118, Issue 6, Page 652-669, December 2022., 2022 TnSmu1 is an integrative and conjugative element (ICE) (a type of mobile element that is transferred from cell to cell via conjugation) found in the genome of the oral pathogen Streptococcus mutans. We found that TnSmu1 is a functional ICE, capable of transfer to recipient cells that lack a copy of TnSmu1.
Lisa K. McLellan +2 more
wiley +1 more source