Results 71 to 80 of about 75,567 (173)
Dual cross‐sectional and longitudinal perspective on the continuum of HIV care to disentangle natural epidemic evolution from real progress, Belgium 2014–2022
HIV Medicine, EarlyView.Abstract Introduction
This study provides a comprehensive overview of HIV care by combining cross‐sectional and longitudinal continuum of care (CoC) analyses. Methods
Using national surveillance data 2014–2022, a five‐stage cross‐sectional CoC was calculated among people living with HIV (incl.D. Van Beckhoven, B. Serrien, R. Demeester, J. Van Praet, P. Messiaen, G. Darcis, S. Henrard, P. De Munter, A. Libois, J. Deblonde +9 morewiley +1 more sourceMultifunctional facets of retrovirus integrase
World Journal of Biological Chemistry, 2015 The retrovirus integrase (IN) is responsible for integration of the reverse transcribed linear cDNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the highly conserved CA sequence in the recessed ends.Sibes Bera, Hideki Aihara, Duane P. Grandgenett, Krishan K. Pandey +3 moreopenaire +3 more sourcesAntiretroviral therapy use, self‐reported adherence, and viral suppression among women living with HIV in Canada
HIV Medicine, EarlyView.Abstract Background
Traditionally, ≥95% adherence was recommended for viral suppression (VS). Newer antiretroviral therapy (ART) is now being increasingly prescribed and may be more forgiving of lower adherence. The lifelong nature of ART presents adherence challenges, particularly for women living with HIV. We aimed to describe ART use and examine the Maysaloun Mokaddam, Nadine Kronfli, Nancy L. Sheehan, Araceli Gonzalez Reyes, Danièle Dubuc, Mona Loutfy, Angela Kaida, Alexandra de Pokomandy, on behalf of the CHIWOS research team, Rahma Abdul‐Noor, Aranka Anema, Jonathan Angel, Dada Mamvula Bakombo, Fatimatou Barry, Greta Bauer, Kerrigan Beaver, Marc Boucher, Isabelle Boucoiran, Jason Brophy, Lori Brotto, Ann N. Burchell, Claudette Cardinal, Allison Carter, Lynne Cioppa, Tracey Conway, José Côté, Jasmine Cotnam, Cori d'Ambrumenil, Janice Dayle, Erin Ding, Danièle Dubuc, Janice Duddy, Mylène Fernet, Annette Fraleigh, Peggy Frank, Brenda Gagnier, Marilou Gagnon, Jacqueline Gahagan, Claudine Gasingirwa, Nada Gataric, Rebecca Gormley, Saara Greene, Danielle Groleau, Charlotte Guerlotté, Trevor Hart, Catherine Hankins, Emily Heer, Robert S. Hogg, Terry Howard, Shazia Islam, Joseph Jean‐Gilles, Hermione Jefferis, Evin Jones, Charu Kaushic, Mina Kazemi, Mary Kestler, Maxime Kiboyogo, Marina Klein, Nadine Kronfli, Gladys Kwaramba, Gary Lacasse, Ashley Lacombe‐Duncan, Melanie Lee, Rebecca Lee, Jenny Li, Viviane Lima, Elisa Lloyd‐Smith, Carmen Logie, Evelyn Maan, Valérie Martel‐Lafrenière, Carrie Martin, Renee Masching, Lyne Massie, Melissa Medjuck, Brigitte Ménard, Cari L. Miller, Judy Mitchell, Gerardo Mondragon, Deborah Money, Ken Monteith, Marvelous Muchenje, Florida Mukandamutsa, Mary Ndung'u, Valerie Nicholson, Kelly O'Brien, Nadia O'Brien, Gina Ogilvie, Susanna Ogunnaike‐Cooke, Joanne Otis, Rebeccah Parry, Sophie Patterson, Angela Paul, Doris Peltier, Neora Pick, Alie Pierre, Jeff Powis, Karène Proulx‐Boucher, Corinna Quan, Jesleen Rana, Eric Roth, Danielle Rouleau, Geneviève Rouleau, Sergio Rueda, Kate Salters, Margarite Sanchez, Roger Sandre, Jacquie Sas, Édénia Savoie, Paul Sereda, Stephanie Smith, Marcie Summers, Wangari Tharao, Christina Tom, Cécile Tremblay, Jason Trigg, Sylvie Trottier, Angela Underhill, Anne Wagner, Sharon Walmsley, Clara Wang, Kath Webster, Wendy Wobeser, Denise Wozniak, Mark H. Yudin, Wendy Zhang, Julia Zhu +125 morewiley +1 more sourceTertiary-Treated Municipal Wastewater is a Significant Point Source of Antibiotic Resistance Genes Into Duluth-Superior Harbor [PDF]
, 2011 In this study, the impact of tertiary-treated municipal wastewater on the quantity of several antibiotic resistance determinants in Duluth-Superior Harbor was investigated by collecting surface water and sediment samples from 13 locations in Duluth ...Allen H. K., Alonso A., Amann R. I., Andersson D. I., Arthurson V., Auerbach E. A., Benson D. A., Berhardt A. E., Berhardt A. E., Canton R., Cardinale M., Chopra I., Cotner J. B., David T. Tan, Davies J., Diehl D. L., D’Costa V. M., Ghosh S., Graham D. W., Jessica J. Eichmiller, Levy S. B., Levy S. B., Ling L. L., Lipsitch M., Martínez J., Merlin C., Mi Yan, Moura A., Munir M., Nelson D. K., Novo A., Patrick J. McNamara, Pruden A., Ramsden S. J., Sambrook J., Seurinck S., Smith D. L., Sommer M. O. A., Staley J. T., Storteboom H., Tchobanoglous G., Thioulouse J., Thompson J. D., Timothy M. LaPara, Tucker R. Burch, Xi C., Yi L., Zhang T., Zhang X., Zhang X.-X. +49 morecore +3 more sourcesMetabolic syndrome and Pathobiological Determination of Atherosclerosis in Youth risk score in adolescents with and without perinatally acquired HIV in the Cape Town Adolescent and Antiretroviral Cohort (CTAAC)‐Heart study
HIV Medicine, EarlyView.Abstract Background
Limited data exist describing metabolic syndrome (MetS) and Pathobiological Determinants of Atherosclerosis in Youth (PDAY) coronary arteries (CA) and abdominal aorta (AA) risk scores in youth with HIV in sub‐Saharan Africa.Sahera Dirajlal‐Fargo, Mothabisi Nyathi, Shan Sun, Lauren Balmert Bonner, Morné Kahts, Nana Akua Asafu‐Agyei, Nomawethu Jele, Emma Carkeek, Justine Legbedze, Grace A. McComsey, Matthew Feinstein, Landon Myer, Ntobeko A. B. Ntusi, Heather J. Zar, Jennifer Jao +14 morewiley +1 more sourceInvestigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors [PDF]
, 2011 With the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be ...Casule, Paola, Derudas, Marco, El-Tamany, El-Sayed H, Gomaa, Mohamed F Y, Hasanen, Jehan Abd-Elrazik, Mariani, Alberto, Pala, Nicolino, Sechi, Mario +7 morecore +1 more sourceComparison of treatment‐emergent resistance‐associated mutations and discontinuation due to adverse events among integrase strand transfer inhibitor‐based single‐tablet regimens and cabotegravir + rilpivirine for the treatment of virologically suppressed people with HIV: A systematic literature review and network meta‐analysis
HIV Medicine, EarlyView.Abstract Objective
This study evaluated rates of treatment‐emergent resistance‐associated mutations (TE‐RAMs) and discontinuation due to adverse events (DC‐AEs) across integrase strand transfer inhibitor (INSTI)‐based single‐tablet regimens and injectable cabotegravir + rilpivirine (CAB + RPV) in virologically suppressed people with HIV.Ishfaq Rashid, Nathan R. Unger, Connor Willis, Teerapon Dhippayom, Moti Ramgopal, Elizabeth M. Sherman, Nicholas Yared, Rachel Safran, Edwin Swiatlo, Amy R. Weinberg, Soodi Navadeh, Howard Weston Schmutz, Nathorn Chaiyakunapruk +12 morewiley +1 more sourceFrom ligand to complexes: inhibition of HIV-1 Integrase by beta-diketo acid metal complexes [PDF]
, 2006 Recently, a class of compounds bearing a β-diketo acid moiety have emerged as the most promising lead in anti-HIV-1 IN
drug discovery. It is believed that the β-diketo acid pharmacophoric motif could be
involved in a functional sequestration of one or ...Al-Mawsawi, Laith Q., Bacchi, Alessia, Carcelli, Mauro, Derudas, Marco, Fisicaro, Emilia, Gates, Paul, Neamati, Nouri, Rogolino, Dominga, Sechi, Mario +8 morecore Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]
, 2016 DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...Johnson, Reid C, Lei, Xianbin, Marko, John F, McLean, Meghan M, Xiao, Botao +4 morecore +1 more sourceWillingness to participate in clinical trials and expectations towards antiretroviral therapy among heavily treatment‐experienced people living with HIV: A feasibility survey
HIV Medicine, EarlyView.Abstract Introduction
As life expectancy among persons with HIV on antiretroviral therapy (ART) is increasing, comorbidities and polypharmacy increase. Drug–drug interactions (DDIs) are common among persons with HIV with a history of virological failure, since many are receiving boosted ART.Marie Ballif, Manuela Correia da Silva Saúde, David Haerry, Marcel Stoeckle, Patrick Schmid, Dominique Braun, Alexandra Calmy, Gilles Wandeler, Bernard Surial +8 morewiley +1 more source
