Results 71 to 80 of about 54,271 (286)
Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo
Animal Research and One Health, EarlyView.The investigation identifies the presence of Encephalomyocarditis virus (EMCV), Baboon endogenous virus (BAV), Human endogenous retrovirus (HERV), and Baboon endogenous virus (BaEV) in non‐human primates (NHPs) at the Zoo, indicating potential zoonotic threats.
Ruiying Liang +13 more
wiley +1 more source
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
Nature, 2015 Bacteria and archaea insert spacer sequences acquired from foreign DNAs into CRISPR loci to generate immunological memory. The Escherichia coli Cas1–Cas2 complex mediates spacer acquisition in vivo, but the molecular mechanism of this process is unknown.
James K. Nuñez +3 more
semanticscholar +1 more source
Brujita Integrase: A Simple, Arm-Less, Directionless, and Promiscuous Tyrosine Integrase System [PDF]
Journal of Molecular Biology, 2016 Mycobacteriophage Brujita is an unusual temperate phage in which establishment of superinfection immunity is dependent on chromosomal integration. Integration is mediated by a non-canonical tyrosine integrase (Int) lacking an N-terminal domain typically associated with binding to arm-type sites within the phage attachment site (attP).
Bryce L. Lunt, Graham F. Hatfull
openaire +3 more sources
A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis
ChemBioChem, EarlyView.Herein, a unique sulfotransferase, AdpST, is identified from the adp biosynthetic gene clusters (BGC) in Streptomyces davaonensis DSM101723 and demonstrates that AdpST possesses di‐sulfation activity, which is unprecedented for bacterial phosphoadenosine‐5’‐phosphosulfate (PAPS)‐dependent sulfotransferases. It is further shown that the adp BGC contains
Conor Pulliam +5 more
wiley +1 more source
Microbiology Spectrum, 2022 Moloney murine leukemia virus (MLV) infects BALB/c mice and induces T-cell lymphoma in mice. Retroviral integration is mediated by the interaction of the MLV integrase (IN) with members of the bromodomain and extraterminal motif (BET) protein family ...
Ivan Nombela +12 more
doaj +1 more source
Journal of Infectious Diseases, 2018 Bictegravir (BIC) and cabotegravir (CAB) are the latest available HIV integrase inhibitors in clinical trials. The combination of major integrase inhibitor substitutions G140S/Q148H has been shown to confer high-level resistance to the approved integrase
Wendy W Zhang +5 more
semanticscholar +1 more source
Lamellarin D Acts as an Inhibitor of Type I Collagen Production
ChemMedChem, EarlyView.COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno +19 more
wiley +1 more source
HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
Journal of Virology, 2016 HIV-1 protease (PR), reverse transcriptase (RT), and integrase (IN) variability presents a challenge to laboratories performing genotypic resistance testing.
Soo-Yon Rhee +9 more
semanticscholar +1 more source
Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy [PDF]
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2010 Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined.We identified 29 individuals who exhibited evidence of incomplete viral suppression on a regimen containing an integrase
Wei Huang +11 more
openaire +3 more sources