Results 81 to 90 of about 39,252 (190)

Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress

The Journal of Physiology, EarlyView.
Abstract figure legend Using genetically encoded sensors for NADPH and H2O2 in the living Drosophila nervous system, neuron‐specific PPP knockdown is shown to result in reduced neuronal NADPH levels and elevated neuronal H2O2 levels and oxidative stress.
Stephan Müller, Nina Surina, Andrés Köhler‐Solís, Ioannis Nellas, Astrid Fleige, Sebastian Görtz, Stefanie Schirmeier   +6 more
wiley   +1 more source

Defense Systems and Prophage Detection in Streptococcus mutans Strains

Molecular Oral Microbiology, Volume 41, Issue 2, Page 57-68, April 2026.
ABSTRACT Although the species is extensively studied, limited data are available on antiphage defense systems (APDSs) in Streptococcus mutans. The present study aimed to explore the diversity and the occurrence of APDSs and to search for prophages in the genomes of clinical isolates of S. mutans using bioinformatics tools.
Olivier Claisse, Cas Mosterd, Claire Le Marrec, Johan Samot   +3 more
wiley   +1 more source

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry Reports
Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking
Nafiseh Karimi, Amirreza Dowlati Beirami, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi, Afshin Zarghi   +4 more
doaj   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 952-959, March 2026.
Aims To determine breastmilk concentrations of doravirine via PBPK modelling in combination with a clinical lactation study. As women living with HIV are not able to cease antiretroviral therapy during lactation, it is necessary to establish drug transfer into breastmilk to determine exposure of the infant to antiretroviral drugs and potential risk of ...
Lena van der Wekken‐Pas, David Burger, Rick Greupink, Angela Colbers   +3 more
wiley   +1 more source

Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase

BMC Biotechnology
Background Mammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as full-length IgG display with mammalian glycosylation and its inherent ability to select antibodies with ...
Olli Huhtinen, Stuart Prince, Urpo Lamminmäki, Rune Salbo, Antti Kulmala   +4 more
doaj   +1 more source

Transposable elements: Functional aspects and applications as drivers of crop innovation

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Transposable elements (TEs), which were once relegated to the status of genomic parasites, are today accepted as important agents of plant genome evolution and adaptation. This review integrates evidence pointing to their dual function as drivers of genetic diversity and instability, with a focus on their contribution to phenotypic innovation,
Flávia Layse Belém Medeiros, José Ribamar Costa Ferreira‐Neto, Jarbson Henrique Oliveira Silva, Cinthia Carla Claudino Grangeiro Nunes, Ana Luíza Trajano Mangueira de Melo, Ayug Bezerra Lemos, Madson Allan de Luna‐Aragão, Agnes Angélica Guedes de Barros, Simon Orozco‐Arias, Eliseu Binneck, Francismar Correa Marcelino‐Guimarães, Ana Cristina Brasileiro‐Vidal, Ana Maria Benko‐Iseppon   +12 more
wiley   +1 more source

The Epidemiology of HIV‐1 Resistance to Two‐Drug Regimens in Multicenter Cohort From Poland—A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Concerns about antiretroviral therapy failure are growing among people with HIV receiving two‐drug regimens, as these schemes include fewer active agents, while the prevalence of transmitted resistance in HIV‐1 continues to increase.
Andrzej Załęski, Agnieszka Lembas, Joanna Osińska, Tomasz Dyda, Magdalena Suchacz, Justyna Stempkowska‐Rejek, Justyna Orzechowska, Alicja Wiercińska‐Drapało   +7 more
wiley   +1 more source