Results 81 to 90 of about 84,131 (280)

Cabotegravir, the Long-Acting Integrase Strand Transfer Inhibitor, Potently Inhibits Human T-Cell Lymphotropic Virus Type 1 Transmission in vitro

Frontiers in Medicine, 2022
Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus most prevalent in southwestern Japan, sub-Saharan Africa, Australia, South America, and the Caribbean. Latest figures approximate 10 million people worldwide to be infected with HTLV-1.
Bethany S. Schneiderman, Michal S. Barski, Goedele N. Maertens   +2 more
doaj   +1 more source

Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors

Journal of Global Antimicrobial Resistance, 2020
This study evaluated the emergence of mutations associated with integrase strand transfer inhibitors (INSTI) resistance (INSTI-RMs) and the integrase evolution in human immunodeficiency virus type 1 (HIV-1) infected patients treated with this drug class.The emergence of INSTI-RMs and integrase evolution (estimated as genetic distance between integrase ...
Scutari, Rossana, Alteri, Claudia, Vicenti, Ilaria, Carlo, Domenico Di, Zuccaro, Valentina, Incardona, Francesca, Borghi, Vanni, Bezenchek, Antonia, Andreoni, Massimo, Antinori, Andrea, Perno, Carlo Federico, Cascio, Antonio, De Luca, Andrea, Zazzi, Maurizio, Santoro, Maria Mercedes   +14 more
openaire   +9 more sources

Strategies to Manage Dosing Deviations and Interruptions of Cabotegravir Long‐Acting Intramuscular Injections

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Long‐acting cabotegravir is approved for HIV treatment and prevention. To guide management of dosing deviations and interruptions, concentration‐time profiles for monthly and every 2 months regimens were simulated using a population pharmacokinetic (PPK) model.
Kelong Han, Ronald D. D'Amico, William R. Spreen, Susan L. Ford   +3 more
wiley   +1 more source

Comparative Genomics of 9 Novel Paenibacillus Larvae Bacteriophages [PDF]

, 2016
American Foulbrood Disease, caused by the bacterium Paenibacillus larvae, is one of the most destructive diseases of the honeybee, Apis mellifera. Our group recently published the sequences of 9 new phages with the ability to infect and lyse P.
Amy, Penny S., LeBlanc, Lucy, Stamereilers, Casey, Tsourkas, Philippos K., Yost, Diane   +4 more
core   +2 more sources

HIV-1 Integrase Inhibitors That Are Active against Drug-Resistant Integrase Mutants

Antimicrobial Agents and Chemotherapy, 2020
The currently recommended first-line therapy for HIV-1-infected patients is an integrase (IN) strand transfer inhibitor (INSTI), either dolutegravir (DTG) or bictegravir (BIC), in combination with two nucleoside reverse transcriptase inhibitors (NRTIs). Both DTG and BIC potently inhibit most INSTI-resistant IN mutants selected by the INSTIs raltegravir
Stephen H. Hughes, Dmitry Lyumkis, Dmitry Lyumkis, Xue Zhi Zhao, Dario O. Passos, Terrence R. Burke, Steven J. Smith   +6 more
openaire   +3 more sources

Acidic Nanoparticles Prevent HIV Pre‐Exposure Prophylaxis (PrEP)‐Induced Oligodendrocyte Impairments by Restoring Lysosomal pH in Adolescent Models

Glia, EarlyView.
Pre‐exposure prophylaxis (PrEP) inhibits oligodendrocyte differentiation. PrEP inhibits oligodendrocyte differentiation through lysosome deacidification. Acidic nanoparticles prevent PrEP‐induced inhibition of oligodendrocyte differentiation. ABSTRACT A disproportionate percentage of adolescents are diagnosed with human immunodeficiency virus (HIV) in ...
Caela C. Long, Lindsay K. Festa, Melanie Cruz‐Berrios, Teshawn D. Johnson, Claire H. Mitchell, Kelly L. Jordan‐Sciutto, Judith B. Grinspan   +6 more
wiley   +1 more source

Recent advances in isothermal amplification techniques coupled with clustered regularly interspaced short palindromic repeat/Cas systems

Interdisciplinary Medicine, EarlyView.
Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu, Yajun Hou, Yuhang Cheng, Ziyun Li, Jiawei Zeng, Li Li, Jinyong Luo, Bo Shen   +7 more
wiley   +1 more source

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases, 2010
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 infection.
Daria J. Hazuda, PhD
doaj  

Precise targeted integration by a chimaeric transposase zinc-finger fusion protein [PDF]

, 2010
Transposons of the Tc1/mariner family have been used to integrate foreign DNA stably into the genome of a large variety of different cell types and organisms.
Abdel-Meguid, Amann, Amy L. Bednarz, Beerli, Boyd, Bryan, Bushman, Bushman, Ciuffi, Cockrell, Collins, Daniel, Emmons, Feng, Goulaouic, Hacein-Bey-Abina, Isalan, Ivics, Ivics, Ivics, Ivics, Ivics, Kaneko, Kaneko, Katz, Lampe, Lampe, Lohe, Maeder, Maragathavally, Ni, Pabo, Pavletich, Plasterk, Richardson, Rimphanitchayakit, Sean D. Colloms, Simons, Sorrell, Suckow, Szabo, Tan, Tan, Thomas, Urasaki, Voigt, Wilson, Xiaofeng Feng, Yant, Zhu   +49 more
core   +3 more sources

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source