Results 121 to 130 of about 2,826,854 (328)

Patient‐reported outcomes in clinical trials assessing the effectiveness of cabotegravir + rilpivirine long‐acting injections as antiretroviral therapy: A systematic review

HIV Medicine, EarlyView.
Abstract Introduction: Human immunodeficiency virus‐1 (HIV‐1) continues to have a high global burden, with approximately 39.9 million people currently living with the virus. Despite the clinical success of antiretroviral therapy (ART), adherence remains a significant challenge, often due to emotional distress and HIV‐related stigma.
Dhruv Vinay, Iresh Jayaweera, Meghan Bowman, Don Thiwanka D Wijeratne   +3 more
wiley   +1 more source

Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration

Retrovirology, 2015
BackgroundGenomic integration, an obligate step in the HIV-1 replication cycle, is blocked by the integrase inhibitor raltegravir. A consequence is an excess of unintegrated viral DNA genomes, which undergo intramolecular ligation and accumulate as 2-LTR
Sylvain Thierry, Soundasse Munir, E. Thierry, F. Subra, H. Leh, Alessia Zamborlini, Dyana T. Saenz, D. N. Levy, P. Lesbats, A. Saïb, V. Parissi, E. Poeschla, E. Deprez, O. Delelis   +13 more
semanticscholar   +1 more source

Rapid start with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) as initial treatment in people with human immunodeficiency virus‐1 (HIV‐1): A systematic literature review of clinical and patient‐reported outcomes

HIV Medicine, EarlyView.
Abstract Background Treatment guidelines recommend rapid antiretroviral therapy (ART) initiation among eligible people with HIV to improve treatment outcomes and reduce HIV transmission. Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), an integrase strand transfer inhibitor‐based single‐tablet regimen, is recommended for rapid start in US and
Jade Ghosn, Jeremy Chow, Monica Gandhi, Miguel Górgolas, Aws Al‐Hayani, Hansel Tookes, Max Lee, Emily F. Kaiser, David Malebranche, Fernando Alvarez Bognar, Bhumi Gandhi‐Patel, Lili Dai   +11 more
wiley   +1 more source

Effect of Pyrolysis on the Removal of Antibiotic Resistance Genes and Class I Integrons from Municipal Wastewater Biosolids [PDF]

, 2018
Wastewater biosolids represent a significant reservoir of antibiotic resistance genes (ARGs). While current biosolids treatment technologies can reduce ARG levels in residual wastewater biosolids, observed removal rates vary substantially.
Kappell, Anthony D., Kimbell, Lee, McNamara, Patrick J.   +2 more
core   +1 more source

Diversification of importin-α isoforms in cellular trafficking and disease states. [PDF]

, 2015
The human genome encodes seven isoforms of importin α which are grouped into three subfamilies known as α1, α2 and α3. All isoforms share a fundamentally conserved architecture that consists of an N-terminal, autoinhibitory, importin-β-binding (IBB ...
Ahluwalia, Andrade, Ao, Aratani, Arjomand, Banninger, Bannister, Bao, Bednenko, Ben-Yaakov, Bian, Bian, Boivin, Chang, Chen, Chen, Chen, Cingolani, Conti, Conti, Cook, Cortes, Cuomo, Dahl, de Barros, Depping, Dissanayake, Dolinsky, Donaldson, Du, Fagerlund, Fagerlund, Fagerlund, Fahrenkrog, Fanara, Fischer, Fontes, Fontes, Forwood, Friedrich, Frieman, Gabriel, Ghosh, Giesecke, Gino Cingolani, Glinsky, Goldfarb, Gorlich, Gorlich, Gousias, Gousias, Grundt, Guillemain, Haenni, Han, Hanz, Harreman, Harreman, Hatayama, Hearps, Henikoff, Hogarth, Holt, Hosokawa, Hu, Huang, Huang, Hudjetz, Huenniger, Hugel, Ilmarinen, Isegawa, Jans, Jenkins, Jensen, Jin, Kamata, Kelley, Kim, Kitamura, Kobe, Kohler, Kohler, Kohler, Koksal, Koksal, Kosugi, Kumar, Lai, Lange, Larkin, Laurila, Lee, Levin, Li, Li, Li, Liang, Lin, Liu, Liu, Lott, Lott, Lufei, Ma, Maas, Macara, Mahalakshmi, Marchenko, Marfori, Marshall, Mason, Matsuura, Matsuura, McConville, Mehmood, Melen, Melzer, Meyer, Misheva, Miyamoto, Miyamoto, Miyamoto, Montgomery, Moriyama, Morris, Mortezavi, Nachury, Nadler, Najarro, Nakamura, Nardozzi, Nardozzi, Nishinaka, Nitahara-Kasahara, O'Neill, O'Neill, Okada, Paciorkowski, Page, Papadopoulos, Paterson, Perez-Villar, Perry, Pettersen, Poon, Pujol, Pumroy, Pumroy, Qu, Reid, Reid, Resa-Infante, Resa-Infante, Rivera, Roman, Rona, Rother, Roussos, Ruth A. Pumroy, Sakai, Seki, Sekimoto, Sekimoto, Shabman, Shaw, Shin, Shmidt, Simkus, Sims, Snow, Song, Spanopoulou, Stewart, Sun, Sun, Sun, Tachibana, Takeda, Takeda, Takeda, Talcott, Tarendeau, Tay, Taylor, Tejomurtula, Theiss, Thomas, Torgerson, Tseng, Tsuji, Umegaki, Ushijima, van der Watt, van der Watt, Wagstaff, Wang, Wang, Wang, Wang, Weis, Weis, Welch, Wente, Winnepenninckx, Xu, Yang, Yang, Yano, Yasuhara, Yasuhara, Ye, Yeung, Yeung, Yoshitake, Zachariae, Zhang, Zhen, Zheng, Zhong, Zhou, Zienkiewicz   +221 more
core   +2 more sources

The use of integrase inhibitors in treatment-experienced patients [PDF]

European Journal of Medical Research, 2009
Raltegravir, the first approved HIV-1 integrase inhibitor, is able to block the strand transfer step of the HIV proviral DNA integration process into the cellular host DNA. The selected dosage for the pivotal phase III studies (subsequently approved by the regulatory agencies) was 400mg bid by oral route with or without food.
openaire   +4 more sources

Weight gain on tenofovir alafenamide fumarate‐based therapy compared to tenofovir disoproxil fumarate‐ and abacavir‐based therapy in children and young people living with HIV in Europe

HIV Medicine, EarlyView.
Abstract Objective To compare BMI‐for‐age z‐score (zBMI) changes in treatment‐experienced children and young people living with HIV aged 6 to <25 years on tenofovir alafenamide fumarate (TAF) to those on tenofovir disoproxil fumarate (TDF) and abacavir (ABC).
The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) Study Group, Siobhan Crichton, Hannah Castro, Katja Doerholt, Luminita Ene, Luisa Galli, Tessa Goetghebuer, Sannie Brit Nordly, Christoph Königs, Magdalena Marczynska, Andrea Marongiu, Lars Navér, Marisa Navarro, Antoni Noguera‐Julian, Paolo Paioni, Vana Spoulou, Vinicius Vieira, Charlotte Jackson, Intira Jeannie Collins, Ali Judd, Elizabeth Chappell, Laura Calle Miguel, Borja Guarch‐Ibáñez, John O'Rourke, Katia Prime, Beatriz Ruiz‐Saez, Sandra Soeria‐Atmadja, Anna Turkova   +27 more
wiley   +1 more source

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]

, 2011
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong, Durrant, Jacob D, Gorfe, Alemayehu A, Li, Jikun, McCammon, J Andrew, Oldfield, Eric, Sankovsky, Anna, Zhu, Wei   +7 more
core   +2 more sources

Metabolic dysfunction‐associated liver disease predicts incident liver fibrosis in people with HIV mono‐infection: A cohort study

HIV Medicine, EarlyView.
Abstract Introduction Metabolic dysfunction‐associated liver disease (MASLD) might progress to cirrhosis. We aimed to evaluate the association of MASLD with the risk of developing clinically significant fibrosis (CSF) in people living with HIV (PLWH).
Juliana Fittipaldi, Sandra W. Cardoso, Estevão Portela Nunes, Cristiane Fonseca De Almeida, Patricia Dias De Brito, Valdilea G. Veloso, Beatriz Grinsztejn, Hugo Perazzo   +7 more
wiley   +1 more source

3′-Processing and strand transfer catalysed by retroviral integrase in crystallo [PDF]

, 2012
Retroviral integrase (IN) is responsible for two consecutive reactions, which lead to insertion of a viral DNA copy into a host cell chromosome. Initially, the enzyme removes di- or trinucleotides from viral DNA ends to expose 3′-hydroxyls attached to ...
Cherepanov, Peter, Hare, Stephen, Maertens, Goedele N   +2 more
core   +2 more sources