Journal of the International Association of Providers of AIDS Care, 2019 Non-nucleoside reverse-transcriptase inhibitor plus integrase strand transfer inhibitor–based dual therapies are an attractive simplification, nucleoside reverse transcriptase inhibitor-sparing strategy for experienced human immunodeficiency virus ...
Niccolò Riccardi MD +3 more
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A New Class of HIV-1 Integrase Inhibitors: The 3,3,3‘,3‘-Tetramethyl-1,1‘-spirobi(indan)-5,5‘,6,6‘-tetrol Family [PDF]
, 2000 Valentina Molteni +5 more
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Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV
Drug Design, Development and Therapy, 2015 Christopher E Kandel,1 Sharon L Walmsley1,21Department of Medicine, University of Toronto, Toronto, ON, Canada; 2Division of Infectious Diseases, University Health Network, Toronto, ON, CanadaAbstract: Dolutegravir is the newest integrase strand transfer
Kandel CE, Walmsley SL
doaj
Intracellular Expression of Single-Chain Variable Fragments To Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase [PDF]
, 2001 P Levy-Mintz +9 more
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Effect of Pyrolysis on the Removal of Antibiotic Resistance Genes and Class I Integrons from Municipal Wastewater Biosolids [PDF]
, 2018 Wastewater biosolids represent a significant reservoir of antibiotic resistance genes (ARGs). While current biosolids treatment technologies can reduce ARG levels in residual wastewater biosolids, observed removal rates vary substantially.
Kappell, Anthony D. +2 more
core +1 more source
Heliyon, 2018 Integrase (IN) plays an essential role in HIV-1 replication, by mediating integration of the viral genome into the host cell genome. IN is a potential target of antiretroviral (ARV) therapeutic drugs such as ALLINI, Raltegravir (RAL), and Elvitegravir ...
Hotma Martogi Lorensi Hutapea +2 more
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Inhibition of Human Immunodeficiency Virus Type 1 Isolates by the Integrase Inhibitor L-731,988, a Diketo Acid [PDF]
, 2002 Ryan Reinke +2 more
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Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors
VirusesAllosteric HIV-1 Integrase (IN) Inhibitors or ALLINIs bind at the dimer interface of the IN, away from the enzymatic catalytic site, and disable viral replication by inducing over-multimerization of IN.
Jian Sun, Jacques J. Kessl
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Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques [PDF]
, 2004 Daria J. Hazuda +21 more
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Impact of integrase inhibitors on gut and oral microbiome
, 2022 Human immunodeficiency virus (HIV) infection is now considered a chronic disease thanks to the extended use of antiretroviral treatment (ART). However, chronic immune activation, inflammation, and increased bacterial translocation (BT) could persist in these patients despite ART.
openaire +3 more sources