Results 161 to 170 of about 2,826,854 (328)
Journal of Food Science, Volume 90, Issue 9, September 2025.ABSTRACT The fermented botanical product (FBP) is a complex, primarily plant‐based fermented food that has been popular among consumers for many years. Although FBP may modulate gastrointestinal function, the responsible factors and precise mechanisms remain unclear and speculative.
Kotomi Chikama +8 more
wiley +1 more source
Highlights from the 24th conference on retroviruses and opportunistic infections, 13-16 February 2017, Seattle, Washington, USA [PDF]
, 2017 From the 13th to 16th February 2017, researchers from around the world convened for the 24th annual Conference on Retroviruses and Opportunistic Infections (CROI) at the Washington State Convention Center in Seattle, Washington.
Bhagani, Sanjay +12 more
core +2 more sources
Factors Influencing the Binding of HIV‐1 Protease Inhibitors: Insights from Machine Learning Models
ChemMedChem, Volume 20, Issue 15, August 2, 2025.Machine learning unlocks the secrets of HIV‐1 protease inhibition, paving the way for data‐driven antiviral drug design. This study analyzes crystallographic data from hundreds of protein–ligand complexes, predicting ligand binding affinity with over 85% accuracy.
Yaffa Shalit, Inbal Tuvi‐Arad
wiley +1 more source
Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques [PDF]
, 2004 Daria J. Hazuda +21 more
openalex +1 more source
Impact of integrase inhibitors on gut and oral microbiome
, 2022 Human immunodeficiency virus (HIV) infection is now considered a chronic disease thanks to the extended use of antiretroviral treatment (ART). However, chronic immune activation, inflammation, and increased bacterial translocation (BT) could persist in these patients despite ART.
openaire +3 more sources
Journal of the International AIDS Society, Volume 28, Issue 8, August 2025.Abstract Introduction The ongoing rollout of oral tenofovir‐based pre‐exposure prophylaxis (PrEP) has the potential to reduce HIV‐1 incidence, but HIV drug resistance (HIVDR) in individuals who acquire HIV‐1 on PrEP could threaten the treatment effectiveness of overlapping antiretrovirals (tenofovir/emtricitabine), contribute to development of ...
Urvi M. Parikh +27 more
wiley +1 more source
MedComm, Volume 6, Issue 8, August 2025.Prophages play a significant role in modulating bacterial virulence and pathogenicity. Our results suggest domestication of φSa3int prophage leads to reduced phagocytosis mediating escape of S. aureus from human innate immunity. As such, targeted identification of mobile genetic elements (MGEs) in addition to species and strain identification may lead ...
Roshan Nepal +9 more
wiley +1 more source
Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors
VirusesAllosteric HIV-1 Integrase (IN) Inhibitors or ALLINIs bind at the dimer interface of the IN, away from the enzymatic catalytic site, and disable viral replication by inducing over-multimerization of IN.
Jian Sun, Jacques J. Kessl
doaj +1 more source
Angiotensin II Type 1 Receptor Blocker Usage Prevents Oxidative Stress and Muscle Dysfunction in HIV
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT Background We aimed to elucidate the role of Angiotensin II type 1 receptor (AT1R) blocker usage in muscle wasting and dysfunction related to HIV. Research Design and Methods Appendicular skeletal muscle mass, higher and lower limb strength, and physical fitness were determined in people living with HIV (PWH) using AT1R blockers users (n = 33),
Rafael Deminice +4 more
wiley +1 more source
From ligand to complexes: inhibition of HIV-1 Integrase by beta-diketo acid metal complexes [PDF]
, 2006 Recently, a class of compounds bearing a β-diketo acid moiety have emerged as the most promising lead in anti-HIV-1 IN drug discovery. It is believed that the β-diketo acid pharmacophoric motif could be involved in a functional sequestration of one or ...
Al-Mawsawi, Laith Q. +8 more
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