Results 41 to 50 of about 17,346 (194)

Different Pathways Conferring Integrase Strand-Transfer Inhibitors Resistance

Viruses, 2022
Integrase Strand Transfer Inhibitors (INSTIs) are currently used as the most effective therapy in the treatment of human immunodeficiency virus (HIV) infections.
Clémence Richetta, Nhat Quang Tu, Olivier Delelis   +2 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review

Pathogens and Immunity, 2016
Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV.
Said A. Hassounah, Thibault Mesplède, Mark A. Wainberg   +2 more
doaj   +1 more source

Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study

Head &Neck, EarlyView.
ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange, Mathilde Morisseau, Justin Michel, Thibaut Reverdy, Sylvain Morinière, Amaury Daste, Maxime Humbert, Caroline Viala, Pauline Corbaux, Tiffany Darbas, François‐Régis Ferrand, Valentin Favier, Camille Evrard, Diane Evrard, Delphine Farneti, Sarah Betrian‐Lagarde, Victor Sarradin   +16 more
wiley   +1 more source

Frequency of Major Transmitted Integrase Resistance in Poland Remains Low Despite Change in Subtype Variability

Viruses
With the widespread use of integrase inhibitors and the expanding use of long-acting cabotegravir in both pre-exposure prophylaxis and antiretroviral treatment, molecular surveillance on the transmission of integrase resistance has regained clinical ...
Kaja Mielczak, Karol Serwin, Anna Urbańska, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Elżbieta Mularska, Adam Witor, Paweł Jakubowski, Maria Hlebowicz, Monika Bociąga-Jasik, Elżbieta Jabłonowska, Aleksandra Szymczak, Bartosz Szetela, Władysław Łojewski, Miłosz Parczewski   +14 more
doaj   +1 more source

Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors

Viruses, 2010
The HIV-1 integrase enzyme is essential for integrating the viral DNA into the host chromosome. Infection is aborted in the absence of integration, making integrase an attractive antiviral target. Recently approved inhibitors of integrase bind tightly to
Robert Craigie, Zhiqi Yin
doaj   +1 more source

Non–AIDS‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

International Journal of Cancer, EarlyView.
ABSTRACT People with HIV (PWH) are living longer, but contemporary data on non–AIDS‐defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow‐up was grouped into 2000–2007, 2008–2015, and 2016–2023. Incidence rates (IRs) were calculated
Giacomo Pozza, Maddalena Matone, Letizia Oreni, Giorgia Carrozzo, Beatrice Caloni, Maria Vittoria Cossu, Davide Moschese, Anna Lisa Ridolfo, Cristina Gervasoni, Cinzia Fasola, Nicla La Verde, Davide Dalu, Spinello Antinori, Andrea Gori, Andrea Giacomelli   +14 more
wiley   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Are new antiretroviral treatments increasing the risks of clinical obesity?

Journal of Virus Eradication, 2019
There is growing evidence that the use of integrase inhibitors could lead to statistically significant increases in body weight and even clinical obesity, although it is unclear whether these changes are clinically significant.
Andrew Hill, Laura Waters, Anton Pozniak
doaj   +1 more source

Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross‐Sectional Study Using Cardiac MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Antiretroviral therapy has transformed HIV into a chronic condition, yet cardiac injury remains a major issue. Purpose To assess the ability of cardiac MR imaging markers to predict cardiac injury and disease progression in HIV‐infected individuals. Study Type Prospective.
Chunyan Deng, Wei Sun, Tianhu Gao, Haixia Chen, Lu Liu, Ran Li   +5 more
wiley   +1 more source