Results 31 to 40 of about 3,561 (181)
HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure
Retrovirology, 2009 In a recent summary of integrase sequences, primary integrase inhibitor mutations were rare. In a review of integrase inhibitor-naïve Australian HIV-1 sequences, primary mutations were not identified, although the accessory mutation G140S was detected. A
Wang Bin +5 more
doaj +1 more source
INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay
Viruses, 2021 Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the viral enzyme integrase (IN).
Steven J. Smith +6 more
doaj +1 more source
Targeting the MLL complex in acute leukemia [PDF]
, 2014 Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core +1 more source
AIDS Research and Therapy, 2020 Background In resource-limited settings, multi-experienced HIV infected patients are often prescribed raltegravir for salvage therapy. Patients failing raltegravir-containing regimens require other drugs including other integrase inhibitors.
Aurelio Orta-Resendiz +4 more
doaj +1 more source
Novel therapeutic strategies targeting HIV integrase
BMC Medicine, 2012 Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an ...
Quashie Peter K +2 more
doaj +1 more source
Fluoroquinolones as HIV-1 integrase, topoisomerase I and II inhibitors.
, 2023 Fluoroquinolones as HIV-1 integrase, topoisomerase I and II inhibitors.
Kulsoom Ghulam Ali (14992580) +6 more
core +1 more source
Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence
Viruses, 2015 Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem of ...
Thibault Mesplède, Mark A. Wainberg
doaj +1 more source
Screening of the NIH Clinical Collection for inhibitors of HIV-1 integrase activity
South African Journal of Science, 2018 Drug repurposing offers a validated approach to reduce drug attrition within the drug discovery and development pipeline through the application of known drugs and drug candidates to treat new indications.
Shaakira Abrahams +4 more
doaj +1 more source
Patterns of resistance development with integrase inhibitors in HIV
, 2011 Jean L Mbisa, Supang A Martin, Patricia A CaneVirus Reference Department, Microbiology Services, Health Protection Agency, London, UKAbstract: Raltegravir, the only integrase (IN) inhibitor approved for use in HIV therapy, has recently been licensed ...
Patricia A Cane +5 more
core +1 more source
Infectious Disease Reports, 2022 HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance.
Helene Mens +3 more
doaj +1 more source