Different Pathways Conferring Integrase Strand-Transfer Inhibitors Resistance [PDF]
Viruses, 2022 Integrase Strand Transfer Inhibitors (INSTIs) are currently used as the most effective therapy in the treatment of human immunodeficiency virus (HIV) infections.
Clémence Richetta +2 more
doaj +5 more sources
The Discovery of Indole-2-carboxylic Acid Derivatives as Novel HIV-1 Integrase Strand Transfer Inhibitors [PDF]
Molecules, 2023 As an important antiviral target, HIV-1 integrase plays a key role in the viral life cycle, and five integrase strand transfer inhibitors (INSTIs) have been approved for the treatment of HIV-1 infections so far.
Yu-Chan Wang +8 more
doaj +3 more sources
Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence
Viruses, 2015 Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem of ...
Thibault Mesplède, Mark A. Wainberg
doaj +4 more sources
HIV-1 Integrase Strand Transfer Inhibitors and Neurodevelopment [PDF]
Pharmaceuticals, 2022 Children born to mothers, with or at risk, of human immunodeficiency virus type-1 (HIV-1) infection are on the rise due to affordable access of antiretroviral therapy (ART) to pregnant women or those of childbearing age.
Emma G. Foster +2 more
doaj +3 more sources
Pharmacokinetic drug interactions of integrase strand transfer inhibitors
Current Research in Pharmacology and Drug Discovery, 2021 The integrase strand transfer inhibitor (INSTI)-containing regimens are currently considered as the first-line treatment of human immunodeficiency virus (HIV) infection.
Chi-Hua Lu +5 more
doaj +3 more sources
Inhibition of matrix metalloproteinases by HIV-1 integrase strand transfer inhibitors [PDF]
Frontiers in Toxicology, 2023 More than fifteen million women with the human immunodeficiency virus type-1 (HIV-1) infection are of childbearing age world-wide. Due to improved and affordable access to antiretroviral therapy (ART), the number of in utero antiretroviral drug (ARV ...
Emma G. Foster +6 more
doaj +2 more sources
HIV-1 Genetic Diversity and Transmitted Resistance to Integrase Strand Transfer Inhibitors in Benguela, Angola [PDF]
MicroorganismsAngola is one of the countries with the highest HIV-1 genetic diversity, yet the implications of this diversity for antiretroviral therapy remain insufficiently characterised. Following the introduction of dolutegravir (DTG) in Angola in 2021, evaluating
Isabel S. Godinho +4 more
doaj +2 more sources
Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionSecond-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings.
José Ramón Santos +64 more
doaj +2 more sources
Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2 [PDF]
VirusesRetroviruses perpetuate their survival by incorporating a copy of their genome into the host cell, a critical step catalyzed by the virally encoded integrase.
Irene Wanjiru Kiarie +6 more
doaj +2 more sources
Clinical Outcomes of Integrase Strand Transfer Inhibitors Containing Antiretroviral Therapy in HIV-2: A Narrative Review [PDF]
Infectious Diseases and TherapyThe human immunodeficiency virus type 2 (HIV-2) is a particular subtype of HIV, which is endemic in West Africa and is characterized by a more indolent course than HIV-1.
Wendy J. Boschloo, Berend J. van Welzen
doaj +2 more sources