Results 11 to 20 of about 2,862,567 (165)

Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

Viruses, 2021
Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation INSTIs are effective but can select for resistant viruses.
Steven J. Smith, Xue Zhi Zhao, Dario Oliveira Passos, Dmitry Lyumkis, Terrence R. Burke, Stephen H. Hughes   +5 more
doaj   +2 more sources

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors

mBio, 2017
Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment.
Isabelle Malet, Frédéric Subra, Charlotte Charpentier, Gilles Collin, Diane Descamps, Vincent Calvez, Anne-Geneviève Marcelin, Olivier Delelis   +7 more
doaj   +2 more sources

Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes [PDF]

Retrovirology, 2009
Background Integrase inhibitors are currently being incorporated into highly active antiretroviral therapy (HAART). Due to high HIV variability, integrase inhibitor efficacy must be evaluated against a range of integrase enzymes from different subtypes ...
Kuhl Björn D, Donahue Daniel A, Faltenbacher Verena H, Sloan Richard D, Bar-Magen Tamara, Oliveira Maureen, Xu Hongtao, Wainberg Mark A   +7 more
doaj   +2 more sources

Patterns of resistance development with integrase inhibitors in HIV [PDF]

Infection and Drug Resistance, 2011
Jean L Mbisa, Supang A Martin, Patricia A CaneVirus Reference Department, Microbiology Services, Health Protection Agency, London, UKAbstract: Raltegravir, the only integrase (IN) inhibitor approved for use in HIV therapy, has recently been licensed ...
Jean L Mbisa, Supang A Martin, Patricia A Cane   +2 more
doaj   +2 more sources

Risk of Cardiovascular Events in People with HIV (PWH) Treated with Integrase Strand-Transfer Inhibitors: The Debate Is Not Over; Results of the SCOLTA Study [PDF]

Viruses
Cardiovascular disease (CVD) is common in people with HIV (PWH), and has great impact in terms of morbidity and mortality. Several intertwined mechanisms are believed to play a role in determining the increased risk of CVD, including the effect of ...
Nicolò Corti, Barbara Menzaghi, Giancarlo Orofino, Marta Guastavigna, Filippo Lagi, Antonio Di Biagio, Lucia Taramasso, Giuseppe Vittorio De Socio, Chiara Molteni, Giordano Madeddu, Elena Salomoni, Giovanni Francesco Pellicanò, Emanuele Pontali, Rita Bellagamba, Benedetto Maurizio Celesia, Antonio Cascio, Eleonora Sarchi, Roberto Gulminetti, Leonardo Calza, Paolo Maggi, Giovanni Cenderello, Alessandra Bandera, Maria Aurora Carleo, Katia Falasca, Sergio Ferrara, Salvatore Martini, Giuliana Guadagnino, Goffredo Angioni, Olivia Bargiacchi, Elena Delfina Ricci, Nicola Squillace, Paolo Bonfanti   +31 more
doaj   +2 more sources

Integrase Strand Transfer Inhibitors Are Associated With Incident Diabetes Mellitus in People With Human Immunodeficiency Virus. [PDF]

Clin Infect Dis, 2022
O'Halloran JA, Sahrmann J, Parra-Rodriguez L, Vo DT, Butler AM, Olsen MA, Powderly WG.   +6 more
europepmc   +2 more sources

Impact of HIV infection and integrase strand transfer inhibitors-based treatment on the gut virome. [PDF]

Sci Rep, 2022
Viruses are the most abundant components of the human gut microbiome with a significant impact on health and disease. The effects of human immunodeficiency virus (HIV) infection on gut virome has been scarcely analysed.
Villoslada-Blanco P, Pérez-Matute P, Íñiguez M, Recio-Fernández E, Jansen D, De Coninck L, Close L, Blanco-Navarrete P, Metola L, Ibarra V, Alba J, Matthijnssens J, Oteo JA.   +12 more
europepmc   +2 more sources

HIV-1 resistance patterns to integrase inhibitors in Chilean patients with virological failure on raltegravir-containing regimens

Journal of Virus Eradication, 2020
In this viewpoint we would like to describe our results in terms of resistance pattern in Chilean patients with virological failure (VF) on raltegravir (RAL)-containing-regimens and highlight the need for the concomitant availability of genotypic ...
Pablo Ferrer, Consuelo Rodriguez, Alicia Sciaraffia, Rocío Tordecilla, Veronica Ramos, Magdalena Durán, Carlos Beltrán, Alejandro Afani   +7 more
doaj   +1 more source

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design. [PDF]

PLoS ONE, 2012
A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to the lens epithelium derived growth factor (LEDGF) binding site of the integrase catalytic core domain.
Thomas S Peat, David I Rhodes, Nick Vandegraaff, Giang Le, Jessica A Smith, Lisa J Clark, Eric D Jones, Jonathan A V Coates, Neeranat Thienthong, Janet Newman, Olan Dolezal, Roger Mulder, John H Ryan, G Paul Savage, Craig L Francis, John J Deadman   +15 more
doaj   +1 more source

The proportion of drug-resistant mutations selected by integrase strand transfer inhibitors among adolescents and young adults.

, 2023
The proportion of drug-resistant mutations selected by integrase strand transfer inhibitors among adolescents and young adults.
Godfrey Barabona (11339337), Erick Mboya (14670750), Veryeh Sambu (14670756), Mucho Mizinduko (14670738), Linda Mlunde (3879916), George Ruhago (4326196), Rita Mutagonda (14670744), Jeremiah Mushi (14670753), Joan Rugemalila (14670732), Peter Kunambi (14670735), Frank Msafiri (14223098), George Mgomella (14670759), Amon Sabasaba (14670741), Werner Maokola (12245224), Doreen Kamori (9194397), Said Aboud (214830), Prosper Njau (10761047), Bruno Sunguya (5852507), Davis Amani (14670747), Sabina Mugusi (316245), Tumaini Nagu (3739117), Andrea Pembe (3577391), Takamasa Ueno (240575), Salim Masoud (11339346), Boniface Jullu (5728430), Beatrice Mutayoba (801226), Macdonald Mahiti (11339340)   +26 more
core   +1 more source