Results 141 to 150 of about 31,823 (275)
Molecular Organization in Site-Specific Recombination: The Catalytic Domain of Bacteriophage HP1 Integrase at 2.7 Å Resolution [PDF]
, 1997 Alison B. Hickman +3 more
openalex +1 more source
Obesity Reviews, Volume 26, Issue 7, July 2025.Summary HIV remains a significant health concern, but the advent of antiretroviral therapy (ART) has transformed it into a manageable chronic condition. However, weight gain and obesity pose a substantial challenge for people living with HIV (PLWH). Moreover, the role of lifestyle has not yet been comprehensively investigated.
Giulia Gilberti +5 more
wiley +1 more source
Dolutegravir Inhibits Autophagy In Vitro in a Mouse Blood–Brain Barrier Model
The FASEB Journal, Volume 39, Issue 12, 30 June 2025.Antiretroviral drug dolutegravir inhibits autophagy function in the mouse brain microvascular endothelial cells. Created with BioRender. ABSTRACT Despite the effectiveness and tolerability of antiretroviral therapy (ART) in treating HIV infection, integrase strand transfer inhibitors, particularly dolutegravir (DTG)‐based ART, have been associated with
Chang Huang, Qing Rui Qu, Reina Bendayan
wiley +1 more source
Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase [PDF]
, 1997 Alan Engelman +4 more
openalex +1 more source
A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis
ChemBioChem, Volume 26, Issue 11, June 3, 2025.Herein, a unique sulfotransferase, AdpST, is identified from the adp biosynthetic gene clusters (BGC) in Streptomyces davaonensis DSM101723 and demonstrates that AdpST possesses di‐sulfation activity, which is unprecedented for bacterial phosphoadenosine‐5’‐phosphosulfate (PAPS)‐dependent sulfotransferases. It is further shown that the adp BGC contains
Conor Pulliam +5 more
wiley +1 more source
The Complex Role of CD8+ T Cells in Placental HIV Infection
European Journal of Immunology, Volume 55, Issue 6, June 2025.CD8+ T cells exhibit dual roles at the maternal‐fetal interface supporting tolerance via IL‐10 and TGF‐β and aiding implantation and vascular remodeling through TNF‐α and IFN‐γ. In HIV infection, CD8+ T cells expand, driving inflammation, PD‐L1 upregulation on trophoblasts, and cytotoxic dysfunction via reduced Granzyme B and Perforin, compromising ...
Kimberly Peta +2 more
wiley +1 more source
Human endogenous retrovirus K10 encodes a functional integrase [PDF]
, 1996 Yoshihiro Kitamura +4 more
openalex +1 more source
Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.ABSTRACT Xylella fastidiosa (Xf) is a Gram‐negative bacterial plant pathogen responsible for severe diseases in a variety of economically important crops. A critical aspect of its virulence is the production of extracellular vesicles (EVs). In this study, we discovered that DNA‐binding proteins and nonribosomal RNA‐binding proteins are abundant in the ...
Alessa Ruf +9 more
wiley +1 more source
MicroorganismsAcne vulgaris is a prevalent chronic inflammatory skin disease, most common in adolescence and often persisting into adulthood, leading to severe physical and psychological impacts. The primary etiological factor is Cutibacterium acnes infection.
Xu Li +6 more
doaj +1 more source
, 2014 Genomic analysis of a large set of phages infecting the common hostMycobacterium smegmatis mc2155 shows that they span considerable genetic diversity.
Anders, Kirk R. +40 more
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