Results 151 to 160 of about 9,111 (181)

Detection and Preliminary Genomic Characterization of Poultry-Derived <i>Salmonella enterica</i> from Southern Kazakhstan. [PDF]

Antibiotics (Basel)
Yespembetov B, Kirkimbayeva Z, Abdykalyk A, Akhmetova A, Shevtsov A, Syrym N, Alpysbayeva S, Sarmykova M, Abdimukhtar A, Anarbekova A, Yerzhigit B, Shestakov A, Kozhabergenov N, Usserbayev B, Bulatov Y, Toleukhan A.   +15 more
europepmc   +1 more source

The expression regulation of <i>recA</i> gene and bacterial class 2 integron-associated genes induced by antibiotics. [PDF]

Front Microbiol
Ye J, Sun Q, Wu Q, Xu J, Yang Y, Zhao R, Li Q.   +6 more
europepmc   +1 more source

Long-read metagenomics reveals phage dynamics in the human gut microbiome. [PDF]

Nature
Wirbel J, Hickey AS, Chang D, Enright NJ, Dvorak M, Chanin RB, Schmidtke DT, Bhatt AS.   +7 more
europepmc   +1 more source

Structural basis of DNA recombination catalysis and regulation by ϕC31 integrase

Sun YE, Aspinall L, Joseph AP, Colloms SD, Stark WM, Spagnolo L.   +5 more
europepmc   +1 more source

Variable orthogonality of RDF – large serine integrase interactions within the ϕC31 family

MacDonald AI, Baksh A, Holland A, Shin H, Rice PA, Stark WM, Olorunniji FJ.   +6 more
europepmc   +1 more source

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Integrase

1995
Abstract The linear DNA copy of the HIV genome made by reverse transcription must be integrated into a chromosome of the infected cell in order to be stably maintained and efficiently transcribed. DNA integration is therefore a necessary step in the viral replication cycle. HIV DNA is inserted into the host genome by a specialized DNA
R Craigie, A B Hickman, A Engelman
openaire   +1 more source

Targeting HIV-1 integrase

Expert Opinion on Therapeutic Targets, 2001
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith, Gilles, Sauvé, Jocelyn, Yelle   +2 more
openaire   +2 more sources

Oligomerization of Retrovirus Integrases

2018
Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric 'intasome' complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of ...
Duane P, Grandgenett, Hideki, Aihara
openaire   +2 more sources

Novel integrase inhibitors for HIV

Expert Opinion on Investigational Drugs, 2010
Integrase inhibitors are the newest class of antiretroviral agents developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) currently approved for the treatment of HIV-infected patients, has proven to be a potent and well-tolerated antiretroviral (ARV) agent.
Nicole, Prada, Martin, Markowitz
openaire   +2 more sources

Substrate Recognition by Retroviral Integrases

1999
Substrate recognition by the retroviral IN enzyme is critical for retroviral integration. To catalyze this recombination event, IN must recognize and act on two types of substrates, viral DNA and host DNA, yet the necessary interactions exhibit markedly different degrees of specificity.
M, Katzman, R A, Katz
openaire   +2 more sources