Results 61 to 70 of about 10,473 (233)

Autonomous Control of Gene Expression Using Endogenous Transcription Signals

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Autonomous cell‐based control of heterologous gene expression can simplify batch‐culture bioprocessing by eliminating external monitoring and extrinsic control of culture conditions. Existing approaches use auto‐induction media, synthetic cell‐cell communication systems, or application‐specific biosensors.
Pakpoom Subsoontorn, Drew Endy, Olivier Borkowski   +2 more
wiley   +1 more source

Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons

Mobile DNA, 2011
Background Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens.
Cambray Guillaume, Sanchez-Alberola Neus, Campoy Susana, Guerin Émilie, Da Re Sandra, González-Zorn Bruno, Ploy Marie-Cécile, Barbé Jordi, Mazel Didier, Erill Ivan   +9 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Funcionalidade de serina integrases no controle de interruptores genéticos em plantas [PDF]

, 2020
Tese (doutorado)—Universidade de Brasília, Programa em Rede Multi-Institucional do Pró-Centro-Oeste de Pós-Graduação em Biotecnologia e Biodiversidade, 2020.A biologia sintética tem sido caracterizada por abordagens interdisciplinares voltadas para o ...
Gomide, Mayna da Silveira
core  

Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

eLife, 2020
Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of invading nucleic acids, a process carried out by the Cas1-Cas2 complex that integrates short segments of foreign genetic material (spacers) into the CRISPR locus.
Alison B Hickman, Shweta Kailasan, Pavol Genzor, Astrid D Haase, Fred Dyda   +4 more
doaj   +1 more source

Visible‐Light‐Mediated Synthesis of Biscoumarins Utilizing Photocaged Sulfonic Acid as the Catalyst

European Journal of Organic Chemistry, EarlyView.
A mild visible light approach for the synthesis of biscoumarins utilizing arylazo sulfones as the photoacid generator under 467 nm irradiation is introduced. Throughout the years, biscoumarin derivatives, known for their diverse biological properties, have attracted extensive synthetic interest.
Athina S. J. Shkembi, Stamatis K. Serviou, Valentina Benazzi, Maurizio Fagnoni, Stefano Protti, Christoforos G. Kokotos   +5 more
wiley   +1 more source

Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

eLife, 2020
Molecular examples of evolutionary innovation are scarce and generally involve point mutations. Innovation can occur through larger rearrangements, but here experimental data is extremely limited.
José Antonio Escudero, Aleksandra Nivina, Harry E Kemble, Céline Loot, Olivier Tenaillon, Didier Mazel   +5 more
doaj   +1 more source

Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study

Head &Neck, EarlyView.
ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange, Mathilde Morisseau, Justin Michel, Thibaut Reverdy, Sylvain Morinière, Amaury Daste, Maxime Humbert, Caroline Viala, Pauline Corbaux, Tiffany Darbas, François‐Régis Ferrand, Valentin Favier, Camille Evrard, Diane Evrard, Delphine Farneti, Sarah Betrian‐Lagarde, Victor Sarradin   +16 more
wiley   +1 more source

Non–AIDS‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

International Journal of Cancer, EarlyView.
ABSTRACT People with HIV (PWH) are living longer, but contemporary data on non–AIDS‐defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow‐up was grouped into 2000–2007, 2008–2015, and 2016–2023. Incidence rates (IRs) were calculated
Giacomo Pozza, Maddalena Matone, Letizia Oreni, Giorgia Carrozzo, Beatrice Caloni, Maria Vittoria Cossu, Davide Moschese, Anna Lisa Ridolfo, Cristina Gervasoni, Cinzia Fasola, Nicla La Verde, Davide Dalu, Spinello Antinori, Andrea Gori, Andrea Giacomelli   +14 more
wiley   +1 more source

Attachment site selection and identity in Bxb1 serine integrase-mediated site-specific recombination. [PDF]

PLoS Genetics, 2013
Phage-encoded serine integrases mediate directionally regulated site-specific recombination between short attP and attB DNA sites without host factor requirements.
Shweta Singh, Pallavi Ghosh, Graham F Hatfull   +2 more
doaj   +1 more source