Results 131 to 140 of about 5,237,372 (315)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A generic multi-domain integrated product modeling framework
, 2006 Aiming at achieving a flexible, reconfigurable and integrated product design and development process, a generic product modeling framework is introduced to give full consideration of mass customization and product lifecycle management. Modules, platform,
Zhang WL(张闻雷), Fan YS(范玉顺)
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Integrated modeling of "soft" and "hard" variables in manufacturing. [PDF]
Int J Adv Manuf Technol, 2022 Afy-Shararah M, Salonitis K.
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism. [PDF]
Nat Commun, 2023 Ghanaeian A +12 more
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Applying FAIR4RS principles to develop an integrated modeling environment for the magnetic confinement fusion. [PDF]
Sci Data, 2023 Liu X, Yu Z, Xiang N.
europepmc +1 more source
An integrated urban systems model with GIS [PDF]
The purpose of the research is to develop an integrated urban systems model, which will assist in formulating a better land use-transportation policy by simulating the relationships between land use patterns and travel behavior, integrated with ...
Jinsoo You +2 more
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