Results 151 to 160 of about 5,237,372 (315)

High fidelity optical modeling for the TMT

, 2016
The Thirty Meter Telescope (TMT) is a Ritchey-Chritien optical telescope with a 30-meter diameter primary mirror made up of 492 hexagonal segments. Such a large and complex optical system requires detailed modeling of the optical performance during the ...
Roberts, Lewis C, Jr, Nissly, Carl, Wang, Lianqi, Shelton, J Chris, Piatrou, Piotr, Ellerbroek, Brent, Seo, Byoung-Lee, Troy, Mitchell, Angeli, George, Cho, Myung   +9 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Syst Dyn Rev [PDF]

The long-term management of global disease eradication initiatives involves numerous inherently dynamic processes, health and economic trade-offs, significant uncertainty and variability, rare events with big consequences, complex and inter-related ...

core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Numerical Integration Study of Penetration and Blasting Damage for Composite Underground Protective Structure with Reinforcement Layers

Buildings
In response to the increasing threat of powerful earth-penetrating weapons, underground protective structures typically employ composite structural systems with reinforced steel layers.
Xingji Zhu, Can Zhao, Longjun Xu, Yujin Wang, Shibin Lin, Guochen Zhao   +5 more
doaj   +1 more source

Translating observed household energy behavior to agent-based technology choices in an integrated modeling framework. [PDF]

iScience, 2022
Edelenbosch OY, Miu L, Sachs J, Hawkes A, Tavoni M.   +4 more
europepmc   +1 more source

Integrated Assessment Modeling of Global Climate Change: Much Has Been Learned—Still a Long and Bumpy Road Ahead [PDF]

, 2005
This paper presents a history of integrated assessment modeling of climate change, discussing many relevant modeling studies produced over the last few decades.
Schneider, Stephen, Lane, Janica
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Integrated modeling of extended agro-food supply chains: A systems approach. [PDF]

Eur J Oper Res, 2021
Taghikhah F, Voinov A, Shukla N, Filatova T, Anufriev M.   +4 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source