Results 141 to 150 of about 5,237,372 (315)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Climate change and hydropower resilience in Nepal: an integrated modeling approach in the Madi River Basin

H2Open Journal
Responding to Nepal's hydropower sector's vulnerability to climate change, this study investigates its impact on energy security, focusing on the Madi River Basin's river systems.
Pragya Pokharel, Ram Krishna Regmi
doaj   +1 more source

Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics. [PDF]

Stem Cell Res Ther, 2023
Li S, Yan B, Wu B, Su J, Lu J, Lam TW, Boheler KR, Poon EN, Luo R.   +8 more
europepmc   +1 more source

Knowledge-integrated autoencoder model

Expert Systems with Applications
Data encoding is a common and central operation in most data analysis tasks. The performance of other models downstream in the computational process highly depends on the quality of data encoding. One of the most powerful ways to encode data is using the neural network AutoEncoder (AE) architecture. However, the developers of AE cannot easily influence
Teddy Lazebnik, Liron Simon Keren
openaire   +2 more sources

Modeling the Structure and Performance of Integrated and Independent Producers in the Gulf of Mexico OCS Region [PDF]

, 1995
Summary describing the work completed at Louisiana State University Center for Energy Studies for 'Modeling the Structure and Performance of Integrated and Independent Producers in the Gulf of Mexico OCS Region.' It includes background information on the
Louisiana State University. Center for Energy Studies.
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A quantitative approach on environment-food nexus: integrated modeling and indices for cumulative impact assessment of farm management practices. [PDF]

PeerJ, 2023
Jamshidi S, Naderi A.
europepmc   +1 more source

A logical model of conceptual integrity in data integration

Journal of Research of the National Institute of Standards and Technology, 2003
Conceptual integrity is required for the result of data integration to be cohesive and sensible. Compromised conceptual integrity results in "semantic faults," which are commonly blamed for latent integration bugs. A logical model of conceptual integrity in data integration and a simple example application are presented. Unlike constructive models that
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Towards integrated modeling of the long-term impacts of oil spills. [PDF]

Mar Policy, 2021
Solo-Gabriele HM, Fiddaman T, Mauritzen C, Ainsworth C, Abramson DM, Berenshtein I, Chassignet EP, Chen SS, Conmy RN, Court CD, Dewar WK, Farrington JW, Feldman MG, Ferguson AC, Fetherston-Resch E, French-McCay D, Hale C, He R, Kourafalou VH, Lee K, Liu Y, Masi M, Maung-Douglass ES, Morey SL, Murawski SA, Paris CB, Perlin N, Pulster EL, Quigg A, Reed DJ, Ruzicka JJ, Sandifer PA, Shepherd JG, Singer BH, Stukel MR, Sutton TT, Weisberg RH, Wiesenburg D, Wilson CA, Wilson M, Wowk KM, Yanoff C, Yoskowitz D.   +42 more
europepmc   +1 more source