Results 161 to 170 of about 5,237,372 (315)

Time-dependent scenario modeling for the ST-E1 fusion power plant

Nuclear Fusion
ST-E1 is a low aspect ratio fusion power plant being designed by Tokamak Energy targeting 1.5 GW of fusion power. Characterization of the ST-E1 flat-top scenario is described elsewhere McNamara et al (2026 Nucl.
X. Zhang, N.A. Lopez, M. Borscz, J. Kang, Y. Takase, M. Scarpari, C. Marsden, M. Ono, S.A.M. McNamara, E.N.J. Maartensson, M. Gorelenkova, A. Pankin, N. Bertelli, S. Shiraiwa   +13 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Design of a high- operation scenario for the HL-3 tokamak

Nuclear Fusion
Future fusion reactors require high normalized beta ( $\beta_\mathrm{N}$ ) operation to achieve economically attractive power density. High- $\beta_\mathrm{N}$ operation is also a key objective for the HL-3 tokamak.
G.Q. Dong, G.Z. Hao, J.X. Li, Y.R. Zhu, S. Wang, Y.P. Zou, Z. Wang, Z.J. Li, H.L. Du, Y.J. Zhou, P.L. Liu, H.Z. Zhao, Y. Zhang, S.L. Zhang, L. Xue, Z. Chen, W.L. Zhong   +16 more
doaj   +1 more source

A hybrid modeling approach for assessing mechanistic models of small molecule partitioning in vivo using a machine learning-integrated modeling platform. [PDF]

Sci Rep, 2021
Antontsev V, Jagarapu A, Bundey Y, Hou H, Khotimchenko M, Walsh J, Varshney J.   +6 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Models for model integration

, 2017
This is a presentation given at the Crops in silico 2nd Annual Symposium and Workshop, Oxford, UK, 27 June 2017. It covers some ideas about different types of models and how they can be put together using frameworks, as well as how one specific tool, the Parsl python parallel scripting library, can be used to assemble and execute loosely-coupled ...
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

An ALM Model for Pension Funds using Integrated Chance Constraints [PDF]

We discuss integrated chance constraints in their role of short-term risk constraints in a strategic ALM model for Dutch pension funds. The problem is set up as a multistage recourse model, with special attention for modeling the guidelines proposed by ...
Streutker, M.H., Klein Haneveld, W.K.., Vlerk, M.H. van der   +2 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source