Results 101 to 110 of about 311,604 (320)

Technology challenges for space interferometry: the option of mid-infrared integrated optics

, 2007
Nulling interferometry is a technique providing high angular resolution which is the core of the space missions Darwin and the Terrestrail Planet Finder. The first objective is to reach a deep degree of starlight cancelation in the range 6 -- 20 microns,
A. Pradel, Angel, Angel, Beichman, Berger, Bracewell, C. Vigreux-Bercovici, Coudé du Foresto, E. LeCoarer, Fridlund, J.-E. Broquin, L. Labadie, Labadie, Labadie, Labadie, Léger, Marcuse, Mennesson, Ollivier, P. Kern, P. Labeye, Palik, Perrin, Shalem, Tien, Tien, V. Kirschner, Vigreux-Bercovici, Vigreux-Bercovici, Wallner, Wehmeier   +30 more
core   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Deuterated SiNx: a low-loss, back-end CMOS-compatible platform for nonlinear integrated optics. [PDF]

Nanophotonics, 2023
Chia XX, Tan DTH.
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Amplitude-Multiplexed readout of single photon detectors based on superconducting nanowires

, 2018
The realization of large-scale photonic circuit for quantum optics experiments at telecom wavelengths requires an increasing number of integrated detectors.
Cernansky, Robert, Chiarello, Fabio, Gaggero, Alessandro, Leoni, Roberto, Martini, Francesco, Mattioli, Francesco, Politi, Alberto   +6 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Review of Optical Fiber Optofluidic Chemical Sensors and Biosensors

Photonic Sensors
Optical fiber sensors have gained significant attention in recent years owing to their remarkable advantages of remote operation and rapid response. The integration of optical fiber sensing with the microfluidics technology has paved the way for the ...
Shuai Gao, Xinyu Yang, Shengjia Wang, Chu Chu, Pingping Teng, Fengjun Tian, Yu Zhang, Zhihai Liu, Xinghua Yang   +8 more
doaj   +1 more source

Terahertz resonant transmission through metallic mesh truss structures

AIP Advances, 2019
In mechanical engineering, truss structures have attracted much attention because of their mechanical strength and light weight. However, electromagnetic properties of truss structures have been rarely reported.
Chul Kang, Seong Han Kim, Gyuseok Lee, Inhee Maeng, Seung Chul Han, Kiju Kang, Chul-Sik Kee   +6 more
doaj   +1 more source