Results 111 to 120 of about 311,065 (292)

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

Opto-PCB: Three demonstrators for optical interconnections [PDF]

, 2008
We report on a research project targeting optical waveguide integrated PCBs conducted within the European FP6 Network of Excellence on Micro-Optics NEMO.
Alajoki, T., Debaes, C., Destouches, N., Franc, J., Hendrickx, Nina, Karioja, P., Karppinen, M., Parriaux, O., Suyal, H., Taghizadeh, M., Thienpont, H., Van Daele, Peter, Van Erps, J., Van Steenberge, Geert, Vervaeke, M.   +14 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization entangled state measurement on a chip

, 2010
The emerging strategy to overcome the limitations of bulk quantum optics consists of taking advantage of the robustness and compactness achievable by the integrated waveguide technology. Here we report the realization of a directional coupler, fabricated
Crespi, A., Mataloni, P., Osellame, R., Ramponi, R., Sansoni, L., Sciarrino, F., Vallone, G.   +6 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Technology challenges for space interferometry: the option of mid-infrared integrated optics

, 2007
Nulling interferometry is a technique providing high angular resolution which is the core of the space missions Darwin and the Terrestrail Planet Finder. The first objective is to reach a deep degree of starlight cancelation in the range 6 -- 20 microns,
A. Pradel, Angel, Angel, Beichman, Berger, Bracewell, C. Vigreux-Bercovici, Coudé du Foresto, E. LeCoarer, Fridlund, J.-E. Broquin, L. Labadie, Labadie, Labadie, Labadie, Léger, Marcuse, Mennesson, Ollivier, P. Kern, P. Labeye, Palik, Perrin, Shalem, Tien, Tien, V. Kirschner, Vigreux-Bercovici, Vigreux-Bercovici, Wallner, Wehmeier   +30 more
core   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Fiber optic sensors [PDF]

A survey of the developments in the field of fiber optics sensor technology is presented along with a discussion of the advantages of optical measuring instruments as compared with electronic sensors.
Hesse, J., Sohler, W.
core   +1 more source

First fringes with an integrated-optics beam combiner at 10 um - A new step towards instrument miniaturization for mid-infrared interferometry

, 2011
Observations at mas-resolution scales and high dynamic range hold a central place in achieving, for instance, the spectroscopic characterization of exo-Earths or the detailed mapping of their protoplanetary disc birthplace.
Anheier, Norman C., Arezki, Brahim, Bernacki, Bruce, Kern, Pierre, Labadie, Lucas, Martin, Guillermo, Qiao, H. A.   +6 more
core   +3 more sources