Results 91 to 100 of about 298,694 (309)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The New Political Economy of EU State Aid Policy [PDF]

, 2013
Despite its importance and singularity, the EU’s state aid policy has attracted less scholarly attention than other elements of EU competition policy. Introducing the themes addressed by the special issue, this article briefly reviews the development of ...
A McLaughlin, B Amable, B Clift, Bruce Lyons, C Ahlborn, C Crouch, C Crouch, C Ehlermann, DR Collie, DR Collie, FG Wishlade, H Buch-Hansen, H Groeben Von der, H Kassim, H Kassim, H-W Friederiszick, Hussein Kassim, I Ganoulis, JA Brander, L Hancher, L Hancher, L Rubini, M Albert, M Blauberger, M Blauberger, M Cini, M Cini, M Cremona, M Smith, M Smith, M Smith, P Bishop, P Nicolaides   +32 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Translating EU civil protection in the Nordic states – towards a theoretical understanding of the creation of European crisis management capacities. [PDF]

, 2007
This paper analyses how EU civil protection is translated (both in a linguistic/conceptual sense and in an organisational sense) in the Nordic states. The analysis builds on interviews with civil servants and illustrates how European crisis management ...
Britz, Malena.
core  

Vulnerability Assessment of Settlements During Emergencies [PDF]

, 2018
During emergencies which occur as a result of uncontrolled effects of natural disasters, major technical and technological accidents and major epidemics of infectious diseases, the health and life of people and the persistent environmental degradation ...
Djordvevic, Amelija, Radosavljevic, Jasmina, Ristic, Dejan, Vukadinovic, Ana   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Design of a Solar Energy Storage Emergency Rescue Backpack Integrated With Global Positioning System, Light Emitting Diode, and a Heating Module

Energy Science & Engineering
Mountain climbing often involves sudden weather changes, group separation, and mobile device battery depletion, which can lead to life‐threatening emergencies.
Jian‐Sheng Huang, Li‐Chin Shih
doaj   +1 more source

A modular casing while drilling rig for large-diameter horizontal boreholes for underground rescue

Meitian dizhi yu kantan
ObjectiveOperations in a narrow space pose a challenge to rescue in the case of the collapse of mine roadways or tunnels. To address this challenge, this study developed a modular rescue casing while drilling (CwD) rig system for horizontal boreholes ...
Dong FAN, Xiaoyang NI, Shuyuan MU, Zujie ZOU, Guojun WEN, Yingping LI, Feifei LU   +6 more
doaj   +1 more source