Results 51 to 60 of about 68,699 (269)
Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu +5 morewiley +1 more sourceUltra-broadband Silicon Photonic Multimode Interference Coupler [PDF]
, 2017 In integrated optics, multimode interference couplers (MMIs) are used as light-wave splitters and combiners in a wide variety of devices ranging from spectrometers to sensors and coherent optical receivers.Cheben, Pavel, Halir, Robert, Luque-González, Jose Manuel, Molina-Fernandez, Iñigo, Ortega-Moñux, Alejandro, Sarmiento-Merenguel, Jose Darío, Schmid, Jens, Wang, Shurui, Wanguemert-Perez, Juan Gonzalo, Xu, Dan-Xia +9 morecore First events from the CNGS neutrino beam detected in the OPERA
experiment [PDF]
, 2006 The OPERA neutrino detector at the underground Gran Sasso Laboratory (LNGS)
was designed to perform the first detection of neutrino oscillations in
appearance mode, through the study of nu_mu to nu_tau oscillations., A Anokhina, A Ariga, A Badertscher, A Bergnoli, A Cazes, A Chukanov, A Di Giovanni, A Ereditato, A Franceschi, A Garfagnini, A Krasnoperov, A Ljubicic, A Longhin, A Malgin, A Marotta, A Nozdrin, A Olchevski, A Paoloni, A Pastore, A Rubbia, A Sadovski, A Schembri, B Carlus, B D Park, B Dulach, B Janutta, B Wonsak, Bahcall J N, C Bozza, C de La Taille, C Di Troia, C Fanin, C Fukushima, C Girerd, C Goellnitz, C Guerin, C Gustavino, C Hagner, C Jollet, C Pistillo, C S Yoon, C Sanelli, C Sirignano, D Autiero, D Di Ferdinando, D Duchesneau, D Frekers, D Kolev, D Orlandi, D Ossetski, D Ryzhikov, Declais Y, E Baussan, E Carrara, F Bersani Greggio, F Dal Corso, F Di Capua, F Grianti, F Juget, F Terranova, G De Lellis, G Felici, G Gaudiot, G Giacomelli, G Grella, G Mandrioli, G Martin-Chassard, G Romano, G Rosa, G Sazhina, G Sirri, G Van Beek, G Wilquet, Guler M (OPERA Collaboration), H Pessard, H Schroeder, H Shibuya, H U Schütz, I G Park, I Kreslo, I Laktineh, I Monteiro, I Tezuka, I Tikhomirov, I Zamboni, J Boucrot, J Damet, J E Campagne, J Ebert, J Favier, J Goldberg, J Janicsko Csathy, J Knuesel, J L Vuilleumier, J Marteau, J P Repellin, J S Song, J Sewing, J Wurtz, K Borer, K Hoshino, K Jakovcic, K Kodama, K Manai, K Morishima, K Niwa, K Pretzl, L Arrabito, L Chaussard, L Consiglio, L Fournier, L Girard, L Meyer, L Patrizii, L Pellegrino, L Raux, L S Esposito, L Scotto Lavina, L Stanco, L Votano, M Ambrosio, M Besnier, M Beyer, M Chernyavsky, M Cozzi, M De Serio, M Dracos, M Giorgini, M Guler, M Hauger, M Hess, M Ieva, M Incurvati, M Kazuyama, M Kimura, M Komatsu, M Messina, M Nakamura, M Natsume, M Pozzato, M Sioli, M Spinetti, M Stipcevic, M T Muciaccia, M Weber, N Agafonova, N Chon-Sen, N D'Ambrosio, N Di Marco, N Naganawa, N Polukhina, N Savvinov, N Starkov, N Ushida, Nakano T, Nakano T, O Giarmana, O Ryazhskaya, O Sato, P Migliozzi, P Monacelli, P Mugnier, P Publichenko, P Strolin, P Tolun, P Vilain, Pontecorvo B, Pontecorvo B, R Acquafredda, R Brugnera, R Ciesielski, R Enikeev, R Gallet, R Spaeti, R Tsenov, R Waldi, R Wurth, R Zimmermann, S Aoki, S Bondil-Blin, S Buontempo, S Dmitrievski, S Dusini, S H Kim, S Lieunard, S Micanovic, S Miyamoto, S Ogawa, S Simone, S Takahashi, T Descombes, T Ferber, T Fukuda, T Hamane, T Hara, T Le Flour, T Nakano, T Napolitano, T Roganova, T Toshito, T Waelchli, U Kose, U Mantello, U Moser, U Ugolino, V A Galkin, V Boyarkin, V Chiarella, V I Galkin, V Matveev, V Pilipenko, V Ryasny, V Saveliev, V Sugonyaev, V Tereschenko, V Tioukov, V Tsarev, V Verguilov, V Yakushev, W Schmidt Parzefall, Y Caffari, Y Déclais, Y Gornoushkin, Y Nonoyama, Y Sato, Y Zaitsev, Z Krumstein +227 morecore +4 more sourcesIntegrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar +13 morewiley +1 more sourceCDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceA Study of the Quasi-elastic (e,e'p) Reaction on $^{12}$C, $^{56}$Fe and
$^{97}$Au
, 2003 We report the results from a systematic study of the quasi-elastic (e,e'p)
reaction on $^{12}$C, $^{56}$Fe and $^{197}$Au performed at Jefferson Lab. We
have measured nuclear transparency and extracted spectral functions (corrected
for radiation) over a ...A. Ahmidouch, A. Klein, A. Lung, A. M. Nathan, A. Mateos, B. Terburg, B. Zeidman, B. Zihlmann, C. Armstrong, C. Bochna, C. Cothran, C. Jackson, C. Jones, C. Keppel, C. Salgado, C. Williamson, C. Yan, D. Abbott, D. Beatty, D. Day, D. DeSchepper, D. Dutta, D. F. Geesaman, D. J. Mack, D. Koltenuk, D. Meekins, D. Potterveld, D. van Westrum, E. Beise, E. Belz, E. E. W. Bruins, E. Kinney, F. Duncan, F. G. Perey, G. Niculescu, H. Breuer, H. E. Jackson, H. Gao, H. Mkrtchyan, H. T. Fortune, I. Niculescu, J. Arrington, J. Arrington, J. Cha, J. D. Walecka, J. Dunne, J. J. Kelly, J. J. Kelly, J. Martin, J. Mitchell, J. O. Hansen, J. P. Schiffer, J. Reinhold, J. W. Price, J. Yu, J.-C. Yang, J.-E. Ducret, K. A. Assamagan, K. Bailey, K. Beard, K. McFarlane, L. Kramer, L. Tang, M. A. Miller, M. Gari, M. Khandaker, N. Chant, O. K. Baker, P. E. Bosted, P. Guèye, P. Markowitz, P. Stoler, R. Carlini, R. E. Segel, R. Ent, R. Gilman, R. Hofstadter, R. J. Holt, R. Madey, R. Milner, R. Mohring, R. Suleiman, S. Barrow, S. Beedoe, S. Danagoulian, S. Frullani, S. Kaufman, S. Wood, T. Eden, T. G. O’Neill, T. P. Welch, Ts. A. Amatuoni, V. Frolov, V. Tadevosyan, W. Hinton, W. J. Cummings, W. Kim, W. Lorenzon, W. Zhao +98 morecore +1 more sourceAngle resolved photoelectron spectroscopy of two-color XUV-NIR ionization with polarization control [PDF]
, 2016 Electron emission caused by extreme ultraviolet (XUV) radiation in the presence of a strong near infrared (NIR) field leads to multiphoton interactions that depend on several parameters.Babies, F., Beckmann, A., Brenner, G., Buck, J., Costello, J., Dammann, L., Düsterer, S., Fanis, A. De, Geßler, P, Geßler, P., Glaser, L., Hartmann, G., Ilchen, M., Johnsson, P., Kabachnik, N. M., Kazansky, A. K., Kelly, T. J., Mazza, T., Meyer, M., Nosik, V. L., Sazhina, I. P., Scholz, F., Seltmann, J., Sotoudi, H., Viefhaus, J. +24 morecore +1 more sourceDual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix +13 morewiley +1 more sourceIII–V-on-Silicon Photonic Integrated Circuits for Spectroscopic Sensing in the 2–4 μm Wavelength Range
Sensors, 2017 The availability of silicon photonic integrated circuits (ICs) in the 2–4 μm wavelength range enables miniature optical sensors for trace gas and bio-molecule detection.Ruijun Wang, Anton Vasiliev, Muhammad Muneeb, Aditya Malik, Stephan Sprengel, Gerhard Boehm, Markus-Christian Amann, Ieva Šimonytė, Augustinas Vizbaras, Kristijonas Vizbaras, Roel Baets, Gunther Roelkens +11 moredoaj +1 more source
