Results 111 to 120 of about 2,158,083 (298)

INTEGRATING ECONOMY SYSTEMS OF RUSSIAN REGIONS INTO GLOBAL VALUE CHAINS: FACTORS AND CONDITIONS

Вестник Северо-Кавказского федерального университета, 2022
In the era of globalization the world economy could be characterized by the process of creating global value chains (GVC). Due to the participation in GVC national companies could get excess to the global export markets, high technologies and expertise ...
Marina Volkova, Yurii Yerygin
doaj  

A voyage to Mars: A challenge to collaboration between man and machines [PDF]

A speech addressing the design of man machine systems for exploration of space beyond Earth orbit from the human factors perspective is presented.
Statler, Irving C.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A typhoon-induced debris flow warning model integrating rainfall thresholds with geological factors

Frontiers in Earth Science
Typhoon-induced debris flows pose a significant threat to the southeastern coastal regions of China. The existing typhoon-induced debris flow warning models, however, are largely limited in the refinement of their rainfall thresholds and in their lack of
Yiming Wang, Yiming Wang, Dengcai Xu, Youjian Yang, Minglang Zhou, Wenqing Chen, Wei Lin   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The on-line tutorial: developing and evaluating resources and disseminating experience [PDF]

, 2004
This is an ESCalate development project awarded to Kerry Shephard, University of Southampton in 2005. It looked at developing practical approaches to integrating a range of commonly available e-learning tools to facilitate wider use of the On-line ...
Furneaux, Clare, Haslam, Paul, Hutchings, Maggie, Shephard, Kerry   +3 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Finding Liouvillian First Integrals of Rational ODEs of Any Order in Finite Terms

Symmetry, Integrability and Geometry: Methods and Applications, 2006
It is known, due to Mordukhai-Boltovski, Ritt, Prelle, Singer, Christopher and others, that if a given rational ODE has a Liouvillian first integral then the corresponding integrating factor of the ODE must be of a very special form of a product of ...
Yuri N. Kosovtsov
doaj