Results 121 to 130 of about 7,800,417 (330)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Water, Health, and Social Technologies: One Million Cisterns Programme Case Study

Annals of Global Health
Background: This paper focuses on the impacts of climate change on vulnerable ecosystems and its implications for the health and well-being of populations.
José Firmino de Sousa Filho, Walisson Angélico de Araújo, Mariana Sebastião, Adalton Fonseca, Raíza Tourinho, Denise Pimenta, Gervásio Santos, Lucas Emanuel, Roberto F. S. Andrade, Gustavo Casais, Gisele Paixão, Andrea Ferreira, Rachel Coelho, Maria Yuri Ichihara, Júlia Pescarini, Joanna M. N. Guimarães, Paulo Victor da Costa, Ismael Silveira, Rafael Silva, Rita Ribeiro, Maurício L. Barreto, On behalf of the SEDHI team   +21 more
doaj   +1 more source

Integrating with integrity [PDF]

Nature Genetics, 2010
openaire   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A Practical Bearing Failure Detection Method Using a New Efficient Deep Network With the Knowledge Self-Adaptive Evolution

Shock and Vibration
Intelligent fault diagnosis technology based on the deep neural network has shown significant advancements in recent years. However, it is difficult and expensive to deploy a fault diagnosis neural network with a huge number of parameters to an embedded ...
Mengyu Ji, Lijun Chen, Yeming Yao, Xiaoping Wang, Cheng Chang, Yunan Zhou   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Introducing a New Journal: BIO Integration

BIO Integration, 2020
Zhiyi Chen, Pintong Huang
doaj   +1 more source

Integration or Predictability? A Further Specification of the Functional Role of Gamma Oscillations in Language Comprehension [PDF]

, 2012
Lin Wang, Zude Zhu, Marcel Bastiaansen
openalex   +1 more source

Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases [PDF]

, 2021
Manav Kapoor, Michael J. Chao, Emma C. Johnson, Gloriia Novikova, Dongbing Lai, Jacquelyn L. Meyers, Jessica Schulman, John I. Nürnberger, Bernice Porjesz, Yunlong Liu, Victor Hesselbrock, Samual Kuperman, John Kramer, Chella Kamarajan, Ashwini K. Pandey, Laura J. Bierut, John P. Rice, Kathleen K. Bucholz, Marc A. Schuckit, Jay A. Tischfield, Andrew I. Brooks, Ronald P. Hart, Laura Almasy, Danielle M. Dick, Jessica E. Salvatore, Paul A. Slesinger, Tatiana Foroud, Howard J. Edenberg, Edoardo Marcora, Arpana Agrawal, Alison Goate   +30 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source