Results 161 to 170 of about 2,401,515 (298)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Gene-sized editing for the therapy of genetic diseases. [PDF]

Funct Integr Genomics
Padureanu T, Cocoș R, Matache IM, Bucur O.   +3 more
europepmc   +1 more source

Integrating critical water issues into long-term planning for WECC.

, 2021
Vincent Tidwell
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Novel Long-Read Sequencing Method for Characterisation of Hepatitis B Transcripts Show High Expression of Chimeric HBV/Human RNA. [PDF]

Liver Int
Stenbäck JB, Ringlander J, Andersson M, Thomsen JHD, Abrahamsson S, Rydell GE, Lindh M.   +6 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by increasing PolΘ protein expression. [PDF]

Proc Natl Acad Sci U S A
Zhu G, Asada S, Abeykoon JP, Sun L, Mukkavalli S, D'Andrea AD.   +5 more
europepmc   +1 more source

Theta activity supports landmark-based correction of naturalistic human path integration [PDF]

Clément Naveilhan, Raphaël Zory, Klaus Gramann, Stephen Ramanoël   +3 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Strategies to integrate non-communicable disease interventions in HIV and tuberculosis care contexts in low- and middle-income countries: a scoping review. [PDF]

BMJ Glob Health
Luo L, Kapur R, Armstrong-Hough M, Alvarez GG, Moucheraud C, Purtle J, Namusisi KN, Yang L, Raghavan R, Lappen H, Shelley D.   +10 more
europepmc   +1 more source