Results 161 to 170 of about 388,340 (363)
Advanced Healthcare Materials, EarlyView.Synthetic matrix metalloproteinase (MMP)‐degradable polyethylene glycol (PEG)‐based hydrogels are developed to investigate the influence of mechanical and biochemical cues on cardioid development. Matrix stiffness and cell adhesion motifs significantly regulate cardioid formation, chamber morphogenesis, contractile function, and cardioid transcriptome.
Yuanhui Song +6 more
wiley +1 more source
Modeling Platelet P2Y$_1$/$_{12}$ Pathway to Integrin Activation [PDF]
arXivThrough experimental studies, many details of the pathway of integrin $\alpha_{\rm IIb}\beta_3$ activation by ADP during the platelet aggregation process have been mapped out. ADP binds to two separate G protein coupled receptors on platelet surfaces, leading to alterations in the regulation of the small GTPase RAP1.
arxiv
Investigating the inner structure of focal adhesions with single-molecule localization microscopy [PDF]
arXiv, 2017 Cells rely on focal adhesions (FAs) to carry out a variety of important tasks, including motion, environmental sensing, and adhesion to the extracellular matrix. Although attaining a fundamental characterization of FAs is a compelling goal, their extensive complexity and small size, which can be below the diffraction limit, have hindered a full ...
arxiv
The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin [PDF]
, 1993 Zhiren Zhang +5 more
openalex +1 more source
Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee +10 more
wiley +1 more source
Avian neural crest cell attachment to laminin: involvement of divalent cation dependent and independent integrins [PDF]
, 1991 The mechanisms of neural crest cell interaction with laminin were explored using a quantitative cell attachment assay. With increasing substratum concentrations, an increasing percentage of neural crest cells adhere to laminin.
Bronner-Fraser, Marianne +1 more
core
Advanced Healthcare Materials, EarlyView.The study introduces innovative 3D microtissues that replicate the glomerular filtration barrier of the kidney, offering a novel platform for understanding podocytopathies. These microtissues simulate the glomerulus's structure and dynamics, allowing for the modeling of podocyte injuries and drug testing.
Sara Buttό +5 more
wiley +1 more source
Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. [PDF]
, 1991 Kensuke Miyake +3 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.A) SLM generates biomimetic bone scaffolds with consistent porosity but varying TPMS‐Gyroid unit cell designs (TG15, TG20, TG25, TG30). B) By enhancing the expression of ITGB1, TPMS‐Gyroid scaffolds can facilitate osteogenic differentiation in BMSCs and promote M2 polarization in macrophages.
Jing Wang +9 more
wiley +1 more source