Results 251 to 260 of about 272,677 (316)

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Comparative Risk of Cancer Recurrence During Treatment With Biologics: A Meta-Analysis. [PDF]

Gastro Hep Adv
Isufi D, Schwarz CW, Jensen MB, Seidelin J, Skov L, Loft N.   +5 more
europepmc   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

ITGBL1 and RPN1 Mark a Fibrotic NP Subpopulation with Coupled Integrin Signaling and N-Glycosylation Programs in IVDD. [PDF]

J Inflamm Res
Qiang S, Liu Y, Dong Y, Cheng C, Huang Y, Zheng J, Tang C, Zhao S.   +7 more
europepmc   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

A MUC13 Variant Enhances Intestinal Ferric Iron Absorption in Unexplained Hyperferritinemia. [PDF]

Liver Int
Callet J, Sheng YH, He Y, Silva Rodriguez M, Chéry C, Safar R, Barbé F, Bensenane M, Guéant-Rodriguez RM, Namour F, Gauchotte G, Hancock JL, Manceau H, Lefebvre T, Tchernitchko D, Puy H, Florin TH, Begun J, Hooper JD, Bronowicki JP, McGuckin MA, Guéant JL, Oussalah A.   +22 more
europepmc   +1 more source

Subcellular Localization of CD24 Is Associated with Integrin β1 Signaling, Immune Suppression, and Clinical Outcomes Across Human Cancers. [PDF]

Biology (Basel)
Patel B, Curcic M, Eltokhy MA, Alabi F, Eltoukhy O.   +4 more
europepmc   +1 more source

ANGPTL2 overexpression promotes angiogenic responses in human retinal microvascular endothelial cells with accompanying integrin α5β1 molecular changes. [PDF]

Front Med (Lausanne)
Song J, Han X, Chen J, Pan T.
europepmc   +1 more source

The Role of Integrin Family in Atherosclerotic Cardiovascular Disease: A Prospective Cohort Study and Mendelian Randomization Analysis. [PDF]

Biomedicines
Niu M, Feng Y, Shu K, Yang Y, Chen J, Lai Z, Liu B, Peng B.   +7 more
europepmc   +1 more source

RETRACTION: Correlation of Integrin Alpha 7 With Clinicopathological Characteristics and Survival Profiles, as Well as its Regulatory Role in Cell Proliferation, Apoptosis, and Stemness in Non-Small-Cell Lung Cancer. [PDF]

J Clin Lab Anal
europepmc   +1 more source