Results 271 to 280 of about 471,837 (353)

Kindlins regulate integrin- and growth factor-dependent ureteric bud formation. [PDF]

Development
Li S, Bock F, Viquez O, Hassan A, Mathew S, Palamuttam R, Mernaugh G, Dong X, Melzer M, Tantengco M, Carroll T, Terker A, Arroyo JP, Pozzi A, Zent R.   +14 more
europepmc   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Overcoming Regorafenib Resistance in Colorectal Cancer: Synergistic Efficacy of Cilengitide in HT29 and WiDr Cells. [PDF]

Medeni Med J
Boz AB, Semiz Z, Yanar F.
europepmc   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

CLDN5 as a novel modulator of podocyte adhesion to extracellular matrix via β1-integrin binding. [PDF]

J Biol Chem
Wang C, Han J, Fan B, Shen Y, An Y, Kong F, Ge N, Zhang X, Liu H, Wang M, Sun H, Zhou C, Zhao S, Gong Y.   +13 more
europepmc   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Natural Isothiocyanates Block Adhesion and Invasion of Gemcitabine- and Cisplatin-Resistant Bladder Cancer Cell Lines. [PDF]

Molecules
Rutz J, Grein T, Laqua M, Benhassine K, Perktas E, Cinatl J, Thomas A, Chun FK, Haferkamp A, Juengel E, Tsaur I, Markowitsch SD, Blaheta RA.   +12 more
europepmc   +1 more source

Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer. [PDF]

Int J Cancer
Yang X, Qiao Y, Sun Y, Abdelaal T, Schuck K, Abdelrasoul H, De La Torre C, Hermes M, Dong Y, Hu J, Fang C, Huang X, Kahlert C, Herr I, Michalski CW, Kong B.   +15 more
europepmc   +1 more source

Inflammation drives TGFβ1 activation via the αvβ6 integrin-mechanotransduction pathway in human skin. [PDF]

iScience
Jiang X, Sellami S, Kessler J, Bachmann M, Noulet F, Russo B, Brembilla NC, Kaya G, Ivanov AI, Shutova MS, Wehrle-Haller B, Boehncke WH.   +11 more
europepmc   +1 more source

All-atom simulations reveal distinct pathways for α_IIbβ₃ activation by biochemical vs. mechanical cues. [PDF]

Cell Mol Life Sci
Kolasangiani R, Joshi O, Schwartz MA, Bidone TC.   +3 more
europepmc   +1 more source