Results 281 to 290 of about 245,645 (318)
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2014
Cells and extracellular matrix components have complex interactions which are involved in many biological processes throughout the life span. These cell-matrix interactions are mediated by receptors, of which some are integral membrane proteins. The aim of this short article is to review the integrin family, the overall structure of integrins, their ...
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Cells and extracellular matrix components have complex interactions which are involved in many biological processes throughout the life span. These cell-matrix interactions are mediated by receptors, of which some are integral membrane proteins. The aim of this short article is to review the integrin family, the overall structure of integrins, their ...
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Matrix Biology, 1997
Integrins provide dynamic links between cells and extracellular matrix molecules. Although integrins were originally viewed as relatively simple adhesion molecules, it soon became clear that intracellular signal transduction initiated by integrins is centrally involved in many cellular processes.
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Integrins provide dynamic links between cells and extracellular matrix molecules. Although integrins were originally viewed as relatively simple adhesion molecules, it soon became clear that intracellular signal transduction initiated by integrins is centrally involved in many cellular processes.
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Seminars in Reproductive Medicine, 2006
Integrins are the major receptors mediating adhesion to the extracellular matrix. Following ligand binding, conformational changes of integrins induce the recruitment of multiple signaling and scaffolding proteins that connect integrin tails to the actin cytoskeleton and permit activation of signaling pathways regulating cell proliferation, apoptosis ...
Monniaux, Danielle +5 more
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Integrins are the major receptors mediating adhesion to the extracellular matrix. Following ligand binding, conformational changes of integrins induce the recruitment of multiple signaling and scaffolding proteins that connect integrin tails to the actin cytoskeleton and permit activation of signaling pathways regulating cell proliferation, apoptosis ...
Monniaux, Danielle +5 more
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Integrin-linked kinase: integrin’s mysterious partner
Current Opinion in Cell Biology, 2004Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases.
Grashoff, C. +4 more
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Current Opinion in Cell Biology, 2005
Integrin signaling is bidirectional. 'Inside-out' signals regulate integrin affinity for adhesive ligands, and ligand-dependent 'outside-in' signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified ...
Mark H, Ginsberg +2 more
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Integrin signaling is bidirectional. 'Inside-out' signals regulate integrin affinity for adhesive ligands, and ligand-dependent 'outside-in' signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified ...
Mark H, Ginsberg +2 more
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Cellular and Molecular Life Sciences (CMLS), 1999
Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response.
Curley, G P, Blum, H, Humphries, M J
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Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response.
Curley, G P, Blum, H, Humphries, M J
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BioEssays, 1996
AbstractThe integrin family was originally described as a family of adhesion receptors, utilized by cells for attachment to and migration across components of the extracellular matrix. Epithelial cells in adult tissues are generally stationary cells, but these cells nevertheless express several different integrins. This review will discuss the evidence
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AbstractThe integrin family was originally described as a family of adhesion receptors, utilized by cells for attachment to and migration across components of the extracellular matrix. Epithelial cells in adult tissues are generally stationary cells, but these cells nevertheless express several different integrins. This review will discuss the evidence
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Science, 1999
Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it ...
F G, Giancotti, E, Ruoslahti
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Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it ...
F G, Giancotti, E, Ruoslahti
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Current Opinion in Pharmacology, 2002
The inhibition of integrins--cell surface receptors with a crucial role in angiogenesis, tumour cell survival, invasion and metastases--has centred on the alpha(v)beta3 integrin. Work has culminated in two antagonists that are in clinical trials as cancer therapeutics. Other integrins appear to be candidate targets in the light of gene knockout studies.
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The inhibition of integrins--cell surface receptors with a crucial role in angiogenesis, tumour cell survival, invasion and metastases--has centred on the alpha(v)beta3 integrin. Work has culminated in two antagonists that are in clinical trials as cancer therapeutics. Other integrins appear to be candidate targets in the light of gene knockout studies.
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Integrin-linked kinase associated with integrin activation
Blood, 2009AbstractPlatelet integrin αIIbβ3 activation is tightly controlled by intracellular signaling pathways, and several molecules, including talin, have been identified as critical for αIIbβ3 activation. However, the whole pathway associated with αIIbβ3 activation remains to be determined.
Shigenori, Honda +6 more
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