Results 281 to 290 of about 234,137 (355)

β1 Integrins Regulate Keratinocyte Adhesion and Differentiation by Distinct Mechanisms

, 2000
Laurence Lévy, Simon Broad, Dagmar Diekmann, Richard D. Evans, Fiona M. Watt   +4 more
openalex   +2 more sources

A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by β1 and β2 integrins [PDF]

, 2001
Estelle S. Harris, Ann O Shigeoka, Wenhua Li, Roberta H. Adams, Stephen M. Prescott, Thomas M. McIntyre, Guy A. Zimmerman, Diane E. Lorant   +7 more
openalex   +1 more source

The Role of IgE in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate FOXP3+ Tregs

Allergy, EarlyView.
We uncover an unprecedented role for IgE in CD. CD patients, regardless of allergic status and similar to allergic patients, display higher levels of circulating IgE+ and FcεRI+ immune cells, including pDCs, which are concomitant to fewer Tregs. In vitro experiments show that the anti‐IgE monoclonal antibody omalizumab restores the ability of pDCs from
Andrés de la Rocha‐Muñoz, Cristina Benito‐Villalvilla, David Olivares, Sofía Sirvent, Miguel A. García‐Brenes, Alba Angelina, Leticia Martín‐Cruz, Javier Cuesta, Paolo Tassinari, Xavier Jaumont, Carlos Taxonera, Oscar Palomares   +11 more
wiley   +1 more source

Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. [PDF]

Nat Commun
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B.   +26 more
europepmc   +1 more source

The Cytoplasmic Tyrosines of Integrin Subunit β1 Are Involved in Focal Adhesion Kinase Activation

, 2000
Krister Wennerberg, Annika Armulik, Takao Sakai, Marjam Karlsson, Reinhard Fässler, Erik Schaefer, Deane F. Mosher, Staffan Johansson   +7 more
openalex   +1 more source

Expression of dominant-negative and chimeric subunits reveals an essential role for β1 integrin during myelination [PDF]

, 2001
João B. Relvas, Anna Setzu, Wia Baron, Philip C. Buttery, Susan E. LaFlamme, Robin J.M. Franklin, Charles ffrench‐Constant   +6 more
openalex   +1 more source

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

Cancer Cell, 2015
E. Hirata, M. R. Girotti, A. Virós, S. Hooper, B. Spencer‐Dene, M. Matsuda, J. Larkin, R. Marais, E. Sahai   +8 more
semanticscholar   +1 more source

Long‐Term Outcome of Paediatric Crohn's Disease Patients With Deep Ulcerations at Diagnosis

Acta Paediatrica, EarlyView.
ABSTRACT Aim Presence of deep ulcerations (DU) at diagnosis seems to be predictive of a more severe phenotype in adult Crohn's disease (CD). The aim of our study was to investigate if the presence of DU at diagnosis was associated with a more severe disease course over time in children.
Monica S. Ronconi, Antoine Neuraz, Elise Payen, Elie Abi Nader, Cécile Lambe, Florence Campeotto, Cécile Talbotec, Frank M. Ruemmele, Bénédicte Pigneur   +8 more
wiley   +1 more source

Targeting Pyk2 to β1-Integrin–Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase–Null Cells [PDF]

, 2001
Candice K. Klingbeil, Christof R. Hauck, Datsun A. Hsia, Kristian Jones, Shannon R. Reider, David D. Schlaepfer   +5 more
openalex   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source