The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes. [PDF]
Taichen Lin+6 more
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Post‐surgical tumor therapy struggles with recurrence and inefficient healing. Anti‐tumor DNA aptamer functionalized gelatin hydrogels, Apt‐GelMA, simultaneously address both issues by suppressing tumor regrowth via targeted tumor cell inhibition and enhancing wound healing through improved cell adhesion and migration. Their biocompatibility, stability,
Tianyue Li+11 more
wiley +1 more source
Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. [PDF]
Lydia Sorokin+4 more
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Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth+2 more
wiley +1 more source
The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin [PDF]
Zhiren Zhang+5 more
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TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer
Intraperitoneal administration of immunogenic Toll‐like receptor agonist‐modified mesoporous silica nanoparticles leads to rapid internalization by ascites myeloid cells with trafficking to fat‐associated lymphoid clusters. Activation of myeloid cells counters suppressive immune mechanisms associated with peritoneal metastasis, leading to regional and ...
Ben Marwedel+15 more
wiley +1 more source
Toll-like receptors and integrins crosstalk
Immune system recognizes invading microbes at both pathogen and antigen levels. Toll-like receptors (TLRs) play a key role in the first-line defense against pathogens. Major functions of TLRs include cytokine and chemokine production.
Fahd Alhamdan+8 more
doaj +1 more source
Liquid Crystalline Networks Hamper the Malignancy of Cancer Cells
Liquid Crystalline Networks are used as scaffolds for the growth of A375 melanoma cells demonstrating to affect their malignancy. Indeed, only by contact, these materials reduces cell proliferation and colony formation capacity, while increasing the number of senescent cells and promoting the mesenchymal to epithelial transition.
Daniele Martella+9 more
wiley +1 more source
Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. [PDF]
Candece L. Gladson, D A Cheresh
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