Results 121 to 130 of about 210,881 (328)

Unexpected diversity of cnidarian integrins: expression during coral gastrulation

BMC Evolutionary Biology, 2008
Background Adhesion mediated through the integrin family of cell surface receptors is central to early development throughout the Metazoa, playing key roles in cell-extra cellular matrix adhesion and modulation of cadherin activity during the convergence
Ball Eldon E, Hayward David C, Shinzato Chuya, Iguchi Akira, Knack Brent A, Miller David J   +5 more
doaj   +1 more source

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Multiscale model of integrin adhesion assembly.

PLoS Computational Biology, 2019
The ability of adherent cells to form adhesions is critical to numerous phases of their physiology. The assembly of adhesions is mediated by several types of integrins.
Tamara C Bidone, Austin V Skeeters, Patrick W Oakes, Gregory A Voth   +3 more
doaj   +1 more source

Focal adhesions as mechanosensors: the two-spring model [PDF]

BioSystems 83: 225-232 (2006), 2006
Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton. Here we present first steps towards a quantitative understanding of focal adhesions as mechanosensors.
arxiv  

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Integrins regulation of wound healing processes: insights for chronic skin wound therapeutics

Frontiers in Cellular and Infection Microbiology
Integrins are heterodimers composed of non-covalently associated alpha and beta subunits that mediate the dynamic linkage between extracellular adhesion molecules and the intracellular actin cytoskeleton.
Dong Yu, Dong Yu, Zhaoyu Lu, Zhaoyu Lu, Fengsong Nie, Fengsong Nie, Yang Chong, Yang Chong   +7 more
doaj   +1 more source

Optimal shapes and stresses of adherent cells on patterned substrates [PDF]

arXiv, 2013
We investigate a continuum mechanical model for an adherent cell on two dimensional adhesive micropatterned substrates. The cell is modeled as an isotropic and homogeneous elastic material subject to uniform internal contractile stresses. The build-up of tension from cortical actin bundles at the cell periphery is incorporated by introducing an energy ...
arxiv  

Murine mRNA for the β‐subunit of integrin is increased in BALB/c‐3T3 cells entering the G₁ phase from the G₀ state [PDF]

, 1988
Shin‐ichi Tominaga
openalex   +1 more source

Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction

Advanced Functional Materials, EarlyView.
Post‐surgical tumor therapy struggles with recurrence and inefficient healing. Anti‐tumor DNA aptamer functionalized gelatin hydrogels, Apt‐GelMA, simultaneously address both issues by suppressing tumor regrowth via targeted tumor cell inhibition and enhancing wound healing through improved cell adhesion and migration. Their biocompatibility, stability,
Tianyue Li, Xin‐Yi Qian, Zi‐Yuan Li, Hao‐Wen Li, Poh‐Ching Tan, Chenghuizi Hu, Jiajun Jin, Shuang‐Bai Zhou, Qing‐Feng Li, He Tian, Junji Zhang, Itamar Willner   +11 more
wiley   +1 more source

Integrin Targeted Therapeutics

Theranostics, 2011
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes.
Melissa Millard, Srinivas Odde, Nouri Neamati
doaj