Results 321 to 330 of about 299,855 (390)

Swimming induces bone loss via regulating mechanical sensing pathways in bone marrow. [PDF]

Mechanobiol Med
Fu S, Lu Y, Sun W, Chen W, Lin C, Qin A.
europepmc   +1 more source

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

Advanced Science, EarlyView.
This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee, Rut Tejero, Nathaniel Silvia, Anirudh Sattiraju, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou, Guohao Dai   +10 more
wiley   +1 more source

Mechanosignaling via Integrins: Pivotal Players in Liver Fibrosis Progression and Therapy. [PDF]

Cells
Sharip A, Kunz J.
europepmc   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Environmental Toxicants and Their Disruption of Integrin Signaling in Lipid Rafts. [PDF]

Bioessays
Izard T.
europepmc   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

Topological Scaffold‐Based Trispecific Recombinant Protein‐Drug Conjugates for Solid Tumor Eradication

Advanced Science, EarlyView.
A novel tri‐specific recombinant protein and its drug conjugate are developed, named sRP‐EHI and sRPDC‐EHI, which feature a star‐shaped topological structure. It can simultaneously bind the EGFR, HER2, and integrin αvβ3 overexpressed in cancer cells.
Huiyi Jiang, Yang Yuan, Xiaoke Zhang, Weizhi Chen, Hui Mao, Baorui Liu, Xiqun Jiang   +6 more
wiley   +1 more source

Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets. [PDF]

Cancer Med
Bruschi A, Sambri A, Fiore M, Bubbico E, Scollo C, Pace A, Zunarelli R, Montanari A, Cappelli A, Di Prinzio L, De Paolis M.   +10 more
europepmc   +1 more source

Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration

Advanced Science, EarlyView.
This review highlights recent advanced in immunomodulatory biomaterials for bone repair, focusing on design strategies, immune interactions, and clinical potential. Abstract The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive ...
Jianan Li, Ying Qu, Bingyang Chu, Tingkui Wu, Meng Pan, Dong Mo, Lang Li, Yang Ming, Yun Yang, Meng Wang, Xinlong He, Zhiyong Qian   +11 more
wiley   +1 more source