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Environmental integrons: the dark side of the integron world

Trends in Microbiology, 2023
Integrons are bacterial genetic elements notorious for their role in spreading antibiotic resistance in clinical settings. In the natural environment, integrons present a wide and hidden diversity, raising questions as to their broader role in bacterial adaptation.
Eva Sandoval-Quintana   +2 more
openaire   +2 more sources

Integrons

Annual Review of Genetics, 2010
Integrons are genetic elements able to acquire and rearrange open reading frames (ORFs) embedded in gene cassette units and convert them to functional genes by ensuring their correct expression. They were originally identified as a mechanism used by Gram-negative bacteria to collect antibiotic resistance genes and express multiple resistance ...
Cambray, Guillaume   +2 more
openaire   +4 more sources

Super-integrons

Research in Microbiology, 1999
Integrons represent the primary mechanism for antibiotic resistance gene capture and dissemination among gram-negative bacteria. The recent finding of super-integron (SI) structures in the genomes of several bacterial species has expanded their role in genome evolution.
D A, Rowe-Magnus   +2 more
openaire   +2 more sources

Abundance of integrons in halophilic bacteria

Canadian Journal of Microbiology, 2022
Integrons are genetic platforms used for expressing open reading frames (ORFs) arranged in gene cassettes. Excision and integration of gene cassettes are controlled by their associated integron integrase (IntI). Using IntegronFinder software, we analyzed all complete halophilic genomes available in the HaloDom database, along with selected partial ...
Sonbol, Sarah, Siam, Rania
openaire   +2 more sources

Integrons and Superintegrons

2014
Numerous studies have appeared that describe the importance of resistance integrons (RIs) and superintegrons (SIs) in antibiotic resistance, microbial physiology, and environmental adaptation in phylogenetically diverse gram-negative bacteria. This chapter describes the genetic organization of an integron; summarizes the different classes of RIs and ...
Robert A. Bonomo   +2 more
openaire   +1 more source

Integron diversity in marine environments

Environmental Science and Pollution Research, 2015
Integrons are bacterial genetic elements known to be active vectors of antibiotic resistance among clinical bacteria. They are also found in bacterial communities from natural environments. Although integrons have become especially efficient for bacterial adaptation in the particular context of antibiotic usage, their role in natural environments in ...
Abella, Justine   +6 more
openaire   +3 more sources

Integrons: agents of bacterial evolution

Nature Reviews Microbiology, 2006
Integrons are assembly platforms - DNA elements that acquire open reading frames embedded in exogenous gene cassettes and convert them to functional genes by ensuring their correct expression. They were first identified by virtue of their important role in the spread of antibiotic-resistance genes.
openaire   +2 more sources

[Structure and function of integrons].

Enfermedades infecciosas y microbiologia clinica, 2002
Integrons are genetic elements known for their role in the acquisition and expression of genes conferring antibiotic resistance. Integrons have an integrase gene (intI), an attachment site (attI), into which individual resistance genes are inserted and a promotor sequence (Pant), allowing expression of resistance genes (cassette-associated genes ...
Montserrat, Sabaté, Guillem, Prats
openaire   +2 more sources

On the taxonomy and functions of integrons

2022
Integrons are genetic elements that helped precipitate the global antimicrobial resistance crisis. However, the role that integrons have played in the resistance crisis is just a specialised case of their more general role in microbial evolution. Their ability to capture a diverse range of gene cassettes means that they can drive rapid adaptation to ...
openaire   +1 more source

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