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The Genetics of Intellectual Disability [PDF]

Brain Sciences, 2023
Intellectual disability (ID) has a prevalence of ~2–3% in the general population, having a large societal impact. The underlying cause of ID is largely of genetic origin; however, identifying this genetic cause has in the past often led to long diagnostic Odysseys.
Sandra Jansen, Lisenka E. L. M. Vissers, Bert B. A. de Vries   +2 more
openaire   +3 more sources

Reducing the risk of criminal exploitation using multi-systemic therapy (the RESET Study): study protocol for a feasibility study and process evaluation

Pilot and Feasibility Studies, 2023
Background Child criminal exploitation is a form of child abuse that poses a serious risk to the welfare, safety, and wellbeing of young people. Multisystemic therapy (MST) is an intensive family and community-based intervention for young people with ...
N. K. Hayden, S. Flynn, F. Blumenfeld, R. P. Hastings, K. M. Gray, S. Cullen, M. A. Cullen, P. E. Langdon   +7 more
doaj   +1 more source

Urine Organic Acids as Metabolic Indicators for Global Developmental Delay/Intellectual Disability in Chinese Children

Frontiers in Molecular Biosciences, 2021
Objective: The purpose of this study was to search for differential metabolites in urine organic acids, and to characterize metabolic features that can be used to identify metabolites for exploration of global developmental delay (GDD)/intellectual ...
Baiyu Chen, Baiyu Chen, Yalan Zhan, Yalan Zhan, Miriam Kessi, Miriam Kessi, Shimeng Chen, Shimeng Chen, Juan Xiong, Juan Xiong, Xiaolu Deng, Xiaolu Deng, Lifen Yang, Lifen Yang, Jing Peng, Jing Peng, Fei Yin, Fei Yin, Fang He, Fang He   +19 more
doaj   +1 more source

P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells

Nature Communications, 2022
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to ...
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum   +21 more
doaj   +1 more source

Correlation Analyses of Clinical Manifestations and Variant Effects in KCNB1-Related Neurodevelopmental Disorder

Frontiers in Pediatrics, 2022
Objective:Vitro functional analyses of KCNB1 variants have been done to disclose possible pathogenic mechanisms in KCNB1-related neurodevelopmental disorder.
Juan Xiong, Juan Xiong, Zhonghua Liu, Shimeng Chen, Shimeng Chen, Miriam Kessi, Miriam Kessi, Baiyu Chen, Baiyu Chen, Haolin Duan, Haolin Duan, Xiaolu Deng, Xiaolu Deng, Lifen Yang, Lifen Yang, Jing Peng, Jing Peng, Fei Yin, Fei Yin   +18 more
doaj   +1 more source

Treatment for the Benign Childhood Epilepsy With Centrotemporal Spikes: A Monocentric Study

Frontiers in Neurology, 2021
Background and Purpose: To date, there is no specific treatment guideline for the benign childhood epilepsy with centrotemporal spikes (BECTS). Several countries recommend levetiracetam, carbamazepine, sodium valproate, oxcarbazepine, and lamotrigine as ...
Miriam Kessi, Miriam Kessi, Fangling Yan, Fangling Yan, Langui Pan, Langui Pan, Baiyu Chen, Baiyu Chen, Eleonore Olatoutou, Eleonore Olatoutou, Dong Li, Dong Li, Fang He, Fang He, Tibera Rugambwa, Lifen Yang, Lifen Yang, Jing Peng, Jing Peng, Fei Yin, Fei Yin   +20 more
doaj   +1 more source

Intellectual Disability [PDF]

, 2015
Perhaps the most common and most debilitating comorbid disorder with autism spectrum disorder (ASD) is intellectual disability (ID). The overlap of these conditions has been studied extensively. This chapter provides an overview of the research that has been published on the topic.
Peters-Scheffer, N.C., Didden, H.C.M., Lang, R.B.   +2 more
openaire   +2 more sources

Sexuality Among Adolescents and Young Adults With Intellectual Disability: Knowledge, Attitude, and Practices

Journal of Psychosexual Health, 2021
Context: It is generally believed that persons with intellectual disability (PWID) do not have sufficient knowledge about sex and sexuality. As there is not much published work from India, such an attitude of clinicians and caregivers appears more to be ...
Bir Singh Chavan, Wasim Ahmad, Priti Arun, Shivangi Mehta, Nazli, Vani Ratnam, Deepti Raina   +6 more
doaj   +1 more source

The Contribution of HCN Channelopathies in Different Epileptic Syndromes, Mechanisms, Modulators, and Potential Treatment Targets: A Systematic Review

Frontiers in Molecular Neuroscience, 2022
BackgroundHyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA-mediated postsynaptic potentials, thereby suppressing epilepsy.
Miriam Kessi, Miriam Kessi, Miriam Kessi, Jing Peng, Jing Peng, Haolin Duan, Haolin Duan, Hailan He, Hailan He, Baiyu Chen, Baiyu Chen, Juan Xiong, Juan Xiong, Ying Wang, Ying Wang, Lifen Yang, Lifen Yang, Guoli Wang, Guoli Wang, Karlmax Kiprotich, Olumuyiwa A. Bamgbade, Fang He, Fang He, Fei Yin, Fei Yin   +24 more
doaj   +1 more source

University Students with Intellectual Disabilities: Empowerment through Voice

Education Sciences, 2021
People with disabilities have been among the most marginalised groups both within society and within post-secondary/higher education. Over the last two decades, an increasing number of inclusive educational programmes have come into existence both ...
John Kubiak, Des Aston, Marie Devitt, Barbara Ringwood   +3 more
doaj   +1 more source