Results 51 to 60 of about 1,551,617 (305)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

L’américanisation d’un intellectuel français : le cas d’Yves Simon (1903-1961)

Transatlantica, 2014
In 1938, Yves Simon, who taught philosophy at the Paris and Lille Catholic Institutes, received an invitation to teach at Notre Dame University in Indiana.
Florian Michel
doaj   +1 more source

The changing of the guard: groupwork with people who have intellectual disabilities [PDF]

, 2009
This paper considers the impact of service systems on group activities. It describes an inter-professional groupwork project facilitated by a social worker and a community nurse.
A. McClimens, A. Mullender, B. Nirje, B.W. Tuckman, C. Barnes, C.J.G. Gersick, D. Cardore, D. Herd, D. Ward, D.G. Race, F. Kevan, H. Northen, J. Edge, J. Walmsley, J. Walmsley, K. Nichols, L. Staples, M. Cohen, M. Doel, M. Preston-Shoot, P. Reason, P. Trevithick, P. Williams, R. Burke, R. Smith, R. Townsley, R.J. Stancliffe, S-J. Hays, S. Read, S. Russell, S.H. Chia, T. MacKay, T. Tyson, W. Utting   +33 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Book Review : Bellanta, Melissa (2012) Larrikins : A History. Brisbane: University of Queensland Press. [PDF]

, 2012
This book has been painstakingly researched by a scholar whose intellectual competencies span several disciplines: history, sociology, criminology, culture, drama and film studies.
Carrington, Kerry
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

(WP 2011-10) Obituary: Warren J. Samuels (1933-2011) [PDF]

, 2011
This paper examines the research and career of the late Warren J. Samuels (1933-2011), an influential institutionalist economist in the Wisconsin John Commons tradition and well-known historian and methodologist of economics.
Davis, John
core   +1 more source

Hedenius’ Soteriological Argument from Evil [PDF]

, 2012
In this paper I explicate and assess a logical argument from evil put forth by the Swedish analytic philosopher Ingemar Hedenius in his book Tro och vetande, by far the most famous and influential critique of Christianity in Swedish intellectual history.
Kraal, Anders
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Reflections on History and Quality Education [PDF]

, 2004
This essay questions the commonly held assumption that schools today are worse academically than they were in the past. It argues that schools have seldom been chiefly interested in intellectual inquiry.
Kantor, Harvey, Lowe, Robert
core   +1 more source