Results 71 to 80 of about 82,035 (295)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Decrease Of Repeated Contamination Of Packed Deli-cious Meat Products [PDF]

, 2019
The study considers a problem of repeated contamination of delicious products, ready for consumption. The aim of the work is to study the repeated thermal processing of a ready vacuum-packed whole-muscular meat product for inhibiting a surface microbiota.
Azarova, N. (Nadiia), Glushkov, O. (Oleg), Shlapak, H. (Halyna), Synytsia, O. (Olha), Vinnikova, L. (Lydmila)   +4 more
core   +3 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Intelligent pigments and plastics for CO2 detection [PDF]

, 2010
A novel CO2 intelligent pigment is incorporated into a thermoplastic polymer to create a long-lived CO2-sensitive plastic film which is characterised and then compared to a traditional solvent-based CO2 indicator ...
Andrew Mills, Fernandez-Sanchez, Graham A. Skinner, McMurray, Mills, Mills, Mills, Mills, Pauline Grosshans, Schroeder   +9 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

A time-strain monitoring system fabricated via offset lithographic printing [PDF]

, 2009
This paper reports progress in the development of strain sensors fabricated using the Conductive Lithographic Film (CLF) printing process. Strain sensitive structures printed via an unmodified offset lithographic printing press using a silver loaded ...
Evans, PSA, Harrison, DJ, Hay, GI, Simpson, GB, Southee, DJ, Wood, J   +5 more
core  

Cellulosic materials as natural fillers in starch-containing matrix-based films: a review [PDF]

, 2016
In this work, the different cellulosic materials, namely cellulose and lignin are analyzed. In addition, the starch-containing matrices (isolated starch and flour) reinforced with cellulosic materials to be used in packaging applications are described ...
Alvarez, Vera Alejandra, Gutiérrez Carmona, Tomy José   +1 more
core   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

DESIGN APPLIED TO FAMILY AGRICULTURE AND AQUACULTURE BASED ON SOCIAL INNOVATION [PDF]

, 2012
The design has gradually been considered by people as an important element for organizations, reinforcing their identities and consequently their image perceived by the society.
Merino, Giselle
core