Results 41 to 50 of about 16,522 (296)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Detection of changes in temperature extremes during the second half of the 20th century [PDF]
, 2005 Since 1950, the warmest and coldest days and nights of the year have become warmer. Comparing these observations with climate model simulations in an optimal detection analysis shows a significant human influence on patterns of change in extremely warm ...
Brown, S. +4 more
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Carbon uptake and water use in woodlands and forests in southern Australia during an extreme heat wave event in the “Angry Summer” of 2012/2013 [PDF]
Biogeosciences, 2016 As a result of climate change warmer temperatures are projected through the 21st century and are already increasing above modelled predictions. Apart from increases in the mean, warm/hot temperature extremes are expected to become more prevalent in the ...
E. van Gorsel +19 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Energies, 2022 This paper presents the effect of baffle geometry on the charging process of a low-temperature heat storage unit. Four different geometry variants were considered for this purpose. Each of them was simulated and the results were compared.
Beata Pytlik +2 more
doaj +1 more source
Heat flux intensification by vortical flow localization in rotating convection [PDF]
, 2006 The effect of rotation on turbulent convective flow between parallel plates has been assessed with direct numerical simulations. With increasing rotation-rate an interesting transition is observed in the vertical-velocity skewness.
Kunnen, RPJ Rudie +7 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Um transdutor de fluxo de calor: aplicação às edificações [PDF]
, 1986 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.
Guimarães, Gilmar
core