Results 51 to 60 of about 159,995 (298)
The Mechanical Greenhouse: Burial of Heat by Turbulence in Hot Jupiter Atmospheres
, 2010 The intense irradiation received by hot Jupiters suppresses convection in the outer layers of their atmospheres and lowers their cooling rates. "Inflated" hot Jupiters, i.e., those with anomalously large transit radii, require additional sources of heat ...
Mitchell, Jonathan L., Youdin, Andrew N.
core +1 more source
Deduction of temperature fluctuations in transient compression wind tunnels using incompressible turbulent flow data [PDF]
, 2009 Wind tunnels and other aero-thermal experimental facilities are likely to make a contribution to the optimisation of energy and propulsion systems for the foreseeable future.
Buttsworth, D. R., Widodo, A.
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Non-equilibrium of Ionization and the Detection of Hot Plasma in Nanoflare-heated Coronal Loops
, 2008 Impulsive nanoflares are expected to transiently heat the plasma confined in coronal loops to temperatures of the order of 10 MK. Such hot plasma is hardly detected in quiet and active regions, outside flares.
Fabio Reale +6 more
core +1 more source
Quiescent thermal emission from neutron stars in LMXBs [PDF]
, 2015 We monitored the quiescent thermal emission from neutron stars in low-mass X-ray binaries after active periods of intense activity in x-rays (outbursts).
Aguilera, Deborah N. +2 more
core +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Intense summer heat fluxes in artificial turf harm people and environment
Landscape and Urban Planning, 2017 Abstract Artificial turf (AT) sports fields have increasingly replaced natural turf (NT). High AT material-cum-air temperature incurs heat-stress impacts on athletes, demanding better understanding of thermal regimes vis-a-vis weather conditions. Adjacent AT and NT sites in humid-tropical Hong Kong were studied. Four radiant-energy components (direct-
openaire +3 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source