Results 71 to 80 of about 16,522 (296)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Latent Heat Fluxes over Complex Terrain from Airborne Water Vapour and Wind Lidars

, 2009
Tropospheric profiles of water vapour and wind were measured with a differential absorption lidar (DIAL) and a heterodyne detection Doppler wind lidar collo-cated onboard the DLR Falcon research aircraft in the past two years.
Kiemle, Christoph, Fix, Andreas, Rahm, Stephan, Wirth, Martin   +3 more
core  

High-heat flux testing of an interceptive device for an intense proton beam [PDF]

, 2001
An interceptive device referred to here as a scraper has been designed and tested for use in a diagnostic device [1]. The scraper will be used to probe a proton beam in order to detect the formation of beam halo [2].
Nguyen, D. C. (Dinh C.), Rendon, Armando M., Valdiviez, R. (Robert), La Fave, R. P. (Richard P.), Martinez, F. A. (Felix A.), Earley, L. M. (Lawrence M.)   +5 more
core  

Geometric optimization of bodies submitted to an intense heat flux using bifurcated channel nets [PDF]

, 2009
The present work studies the geometric optimization of a body submitted to intense heat flux. The body to be optimized is refrigerated by a ducts system whose circulating fluid will remove the heat.
Isoldi, Liércio André, Elizaldo Domingues dos Santos, Bolzan, Claus de Rosso, Santos, Elizaldo Domingues dos, Rocha, Luiz Alberto Oliveira, Claus de Rosso Bolzan, Luiz Alberto Oliveira Rocha, Liercio André Isoldi   +7 more
core   +1 more source

Estimation of the tidal heating in the TRAPPIST-1 planets

Astronomy & Astrophysics
With the arrival of JWST observations of the TRAPPIST-1 planets – particularly secondary transit depths and phase curves – it is timely to reassess the contribution of tidal heating to their heat budget.
Bolmont Emeline, Sastre Mariana, Revol Alexandre, Kervazo Mathilde, Tobie Gabriel   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The High-Heat Flux Testing of an Interceptive Device for an Intense Proton Beam [PDF]

, 2001
An interceptive device referred to here as a scraper has been designed and tested for use in a diagnostic device [1]. The scraper will be used to probe a proton beam in order to detect the formation of beam halo [2].
Nguyen, Dinh, Martinez, Felix A., LaFave, Richard, Valdiviez, Robert, Earley, Larry, Rendon, Armando   +5 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

SUNCATCH II Verification TEST, SFERA VTS

, 2011
Flussdichte, Sonne, Solarforschung, Kalirometer, Leistung ...
Dibowski, Gerd
core