Results 81 to 90 of about 16,522 (296)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Feedback system for divertor impurity seeding based on real-time measurements of surface heat flux in the Alcator C-Mod tokamak [PDF]
, 2016 Mitigation of the intense heat flux to the divertor is one of the outstanding problems in fusion energy. One technique that has shown promise is impurity seeding, i.e., the injection of low-Z gaseous impurities (typically N2 or Ne) to radiate and ...
Kuang, A. Q. +11 more
core +1 more source
Remote SensingThermal infrared (TIR) time series images acquired by ground, proximal TIR stations provide valuable data to study evolution of surface temperature fields of diffuse degassing volcanic areas.
Fabio Sansivero, Giuseppe Vilardo
doaj +1 more source
Meteorologische Zeitschrift, 1992 A diagnostic model (acronym DIAMOD) for the free atmosphere is described. Core of DIAMOD is a module which calculates complete thermodynamic budgets of latent and sensible heat, including objective imbalance estimates.
M. Dorninger +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Submesoscale Vertical Heat Flux Amplifies a Cross‐Scale Positive Feedback in the Western Arabian Sea
Geophysical Research LettersHigh‐resolution simulations reveal that summer monsoon‐induced upwelling in the western Arabian Sea triggers vigorous submesoscale vertical heat flux (SVHF), challenging the conventional view of winter‐dominant submesoscale activity in open‐ocean ...
Chaoliang Li, Peng Zhan
doaj +1 more source
Dynamics of stratospheric wave reflection over the North Pacific [PDF]
Weather and Climate DynamicsStratospheric wave reflection events involve the upward propagation of planetary waves, which are subsequently reflected downward by the stratospheric polar vortex.
M. K. Schutte +5 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Hydrography and flow in the rift valley of the Mid-Atlantic Ridge
, 2000 Slow-spreading mid-ocean ridges such as the Mid-Atlantic Ridge are characterized by deep axial rift valleys which are isolated from the water on the ridge flanks.
Thurnherr, Andreas M., Thurnherr, A.M.
core