Results 81 to 90 of about 2,481,320 (272)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Blue in green: forestation turns blue water green, mitigating heat at the expense of water availability

Environmental Research Letters
In order to meet a stringent carbon budget, shared socioeconomic pathways (SSPs) aligned with the Paris Agreement typically require substantial land-use changes (LUC), such as large-scale forestation and bioenergy crop plantations.
Olivier Asselin, Martin Leduc, Dominique Paquin, Nathalie de Noblet-Ducoudré, Diana Rechid, Ralf Ludwig   +5 more
doaj   +1 more source

Thermo-Hydraulic Performance of Tubular Heat Exchanger with Opposite-Oriented Trapezoidal Wing Perforated Baffle Plate

Tehnički Glasnik
A detailed experimental study explored a new axial heat exchanger with swirling air over heated tubes. This heat exchanger features circular baffle plates with perforations and trapezoidal air deflectors at different angles.
Md. Atiqur Rahman, S. M. Mozammil Hasnain, Rustem Zairov   +2 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Recrystallization, cracking, and erosion of dispersoid-strengthened tungsten materials during exposure to divertor plasmas

Nuclear Materials and Energy
In this study, we investigated the effects of combined intense particle and heat flux exposure on advanced tungsten plasma-facing materials within the DIII-D fusion facility.
R.D. Kolasinski, J.D. Coburn, D.D. Truong, J.G. Watkins, T. Abrams, Z.Z. Fang, R. Hood, R.E. Nygren, A.W. Leonard, J. Ren, D.L. Rudakov, J. Sugar, C. Tsui, H.Q. Wang, J.A. Whaley, I. Bykov, A. Cruz, F. Glass, J. Herfindal, C. Lasnier, C. Marini, A. McLean, A.L. Moser, R. Nishimoto, R. Wilcox, W. York   +25 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Study of Transient Heat Transfer of Melt in Ellipsoidal Lower Head

Yuanzineng kexue jishu
The in-vessel melt retention (IVR) technology, as one of the typical technologies to cope with severe accidents in third-generation nuclear power, is widely used in pressurized water reactor (PWR) nuclear power plants.
LIU Peng1, 2, 3, ZHOU Tao1, 2, 3, LIU Xiaofang1, 2, 3, ZHANG Haolei1, 2, 3, BAI Zongyan1, 2, 3, DUN Shilei1, 2, 3, MAO Shang4
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source