Results 81 to 90 of about 328,626 (335)

Magnetic flares in accretion disc coronae and the Spectral States of black hole candidates: the case of GX 339-4 [PDF]

, 1998
We present a model for the different X-ray spectral states displayed by Galactic Black Hole Candidates (GBHC). We discuss the physical and spectral implications for a magnetically structured corona in which magnetic flares result from reconnection of ...
Celotti, A., Di Matteo, T., Fabian, A. C.   +2 more
core   +3 more sources

Anisotropic heating and parallel heat flux in electron-only magnetic reconnection with intense guide fields

Journal of Plasma Physics
Electron-only reconnection (E-REC) is a process recently observed in the Earth’s magnetosheath, where magnetic reconnection occurs at electron kinetic scales, and ions do not couple to the reconnection process. Electron-only reconnection is likely to have a significant impact on the energy conversion and dissipation of turbulence cascades at kinetic ...
Jincai Ren, Giuseppe Arrò, Maria Elena Innocenti, Giovanni Lapenta   +3 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Physical Mechanisms for the Variable Spin-down of SGR 1900+14 [PDF]

, 1999
We consider the physical implications of the rapid spindown of Soft Gamma Repeater 1900+14, and of the apparent "braking glitch", \Delta P/P = l x 10^-4, that was concurrent with the Aug. 27th giant flare.
Duncan, R. C., Finger, M. H., Kouveliotou, C., Thompson, C., van Paradijs, J., Woods, P. M.   +5 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Role of Atmospheric Rivers in Antarctic Sea Ice Variations

Geophysical Research Letters, 2023
Antarctic sea ice variations are affected by moisture and heat from low‐ and mid‐latitudes, more than 90% of which are transported by atmospheric rivers (ARs).
Kaixin Liang, Jinfei Wang, Hao Luo, Qinghua Yang   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Observations of an extreme storm in interplanetary space caused by successive coronal mass ejections

, 2014
Space weather refers to dynamic conditions on the Sun and in the space environment of the Earth, which are often driven by solar eruptions and their subsequent interplanetary disturbances.
Bale, Stuart D., Farrugia, Charles J., Galvin, Antoinette B., Kajdič, Primož, Kilpua, Emilia K. J., Lavraud, Benoit, Liu, Ying D., Lugaz, Noé, Luhmann, Janet G., Möstl, Christian, Nitta, Nariaki V.   +10 more
core   +1 more source

Two-electron temperature model of a laser-driven implosion [PDF]

, 1985
The plasma ejected by a pellet irradiated with moderately intense laser light (Icrλ2 ∼1015 W cm−2 μm2, Icr and λ being intensity and wavelength) is analyzed.
Afanas’ev, Albritton, Braithwaite, Estabrook, Forslund, Gitomer, Goldsack, Kruer, Max, Mora, Ramis, Sanz, Sanz, Valeo   +13 more
core   +2 more sources