Results 31 to 40 of about 44,818 (260)

Intensity modulated radiotherapy for elderly bladder cancer patients

Radiation Oncology, 2011
Background To review our experience and evaluate treatment planning using intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) for the treatment of elderly patients with bladder cancer. Methods From November 2006 through November 2009, we
Chong Ngot-Swan, Wu Le-Jung, Hsiao Chi-Huang, Chang Hsiao-Chun, Lai Siu-Kai, Chan Pei-Hui, Chung Shiu-Dong, Hsieh Chen-Hsi, Chen Yu-Jen, Wang Li-Ying, Hsieh Yen-Ping, Shueng Pei-Wei   +11 more
doaj   +1 more source

Current advances in radiotherapy for soft tissue sarcomas

Nowotwory, 2020
Radiotherapy (RT) is a part of the routine treatment of locally advanced or high-grade soft-tissue sarcomas (STS). However, RT has changed significantly over the last 20 years. Modern RT techniques have extended its potential application in STS treatment.
Mateusz J. Spałek, Aneta M. Borkowska
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Intensity modulated radiotherapy (IMRT) in bilateral retinoblastoma

Radiology and Oncology, 2010
External beam radiotherapy (EBRT) for retinoblastoma has traditionally been done with conventional radiotherapy techniques which resulted high doses to the surrounding normal tissues.A 20 month-old girl with group D bilateral retinoblastoma underwent intensity modulated radiotherapy (IMRT) to both eyes after failing chemoreduction and focal therapies ...
Atalar, Banu, Gunduz, Kaan, Gungor, Gorkem, Ozyar, Enis   +3 more
openaire   +4 more sources

Analysis of the therapeutic effect of synchronous integrated intensity modulated radiotherapy combined with chemotherapy in stage IIIc of cervical cancer

Frontiers in Oncology
ObjectiveTo explore the Therapeutic effect of synchronous Integrated intensity modulated radiotherapy combined with chemotherapy in stage IIIc of Cervical CancerMethodsA total of 58 patients with stage IIIC cervical cancer (KPS ≥ 80) were analyzed in ...
Yanru Mu, Hui Wang, Li Xu, Li Shi, Rui Song, Dezhi Wang, Yuhua Gao, Yuhua Gao, Haibo Yan, Haibo Yan   +9 more
doaj   +1 more source

Dosimetric Comparison between 6MV Flattened Filter and Flattening Filter Free Photon Beams in the Treatment of Glioblastoma with IMRT Technique: A Treatment Planning Study [PDF]

Iranian Journal of Medical Physics, 2020
Introduction: The present study evaluated the dosimetric comparison between 6MV flattened filter (FF) and flattening filter-free (FFF) photon beams in intensity-modulated radiation therapy (IMRT) technique for the treatment of glioblastoma (GBM) patients.
Dinesh Saroj, Suresh Yadav, Gopa Ghosh, Shuchishree Shukla, Gaurav Gupta, S. Choudhary   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Efficacy and safety of intensity-modulated radiotherapy alone versus intensity-modulated radiotherapy plus chemotherapy for treatment of intermediate-risk nasopharyngeal carcinoma

Radiation Oncology, 2020
Background This study directs to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) alone versus IMRT plus chemotherapy in intermediate-risk NPC (stage II and T3N0M0).
Omer Aftab, Shufang Liao, Rongjun Zhang, Nan Tang, Meiqing Luo, Bin Zhang, Sanjeev Shahi, Raju Rai, Jazib Ali, Wei Jiang   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The role of intensity modulated radiotherapy in gynecological radiotherapy: Present and future [PDF]

Reports of Practical Oncology & Radiotherapy, 2013
This manuscript reviews the English language literature on the use of intensity modulated radiation therapy (IMRT) for gynecologic malignancies, focusing on the treatment cervical cancer.Radiation therapy plays a key role in both definitive and adjuvant treatment of these patients, although efforts continue to minimize acute and chronic toxicity.
Fernandez-Ots, Ana, Crook, Juanita
openaire   +2 more sources