Results 111 to 120 of about 14,370 (210)

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Feasibility of reduced setup uncertainty in intensity-modulated proton therapy for mediastinal lymphoma. [PDF]

Phys Imaging Radiat Oncol
Pisciotta P, Hengeveld A, Korevaar EW, Visser S, Wagenaar D, Klinker P, Maduro JH, Langendijk JA, Niezink AG, Both S.   +9 more
europepmc   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Quantitative evaluation of taste dysfunction using electrogustometry in patients with head and neck cancer undergoing intensity-modulated radiation therapy and intensity-modulated proton therapy. [PDF]

J Radiat Res
Shima T, Yasuda K, Suzuka M, Yamano S, Takeuchi A, Iwai N, Kanno Y, Dekura Y, Minatogawa H, Fujita Y, Miyazaki T, Koizumi F, Takahashi S, Aoyama H, Minowa K.   +14 more
europepmc   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Comparison of in-field secondary cancer risk based on therapeutic proton dose between proton arc therapy and intensity-modulated proton therapy in lung cancer patients. [PDF]

J Appl Clin Med Phys
Xu Y, Chen W, Wu J, Guo H, Zeng F, Zhang T, Yang F, Huang X, Zhang D, Wang X.   +9 more
europepmc   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Clinical implementation of intensity modulated proton therapy in breath-hold for mediastinal lymphoma patients using surface monitoring and nasal high-flow therapy. [PDF]

Phys Imaging Radiat Oncol
Vilches-Freixas G, van der Klugt K, Canters R, Kneepkens E, Vereijken F, Cobben M, van den Bosch M, Lubken I, van Engelen A, Stultiens C, Velders M, Cartechini G, Unipan M, Berbée M, Ta B.   +14 more
europepmc   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Improved organs-of-interest dose reduction potential with intensity modulated proton therapy and breath-hold in mediastinal lymphoma. [PDF]

Phys Imaging Radiat Oncol
Ta BDP, Canters RAM, van der Klugt K, Vilches-Freixas G, Kneepkens E, Vereijken F, Cobben M, van den Bosch M, Lubken I, Stultiens C, Velders M, Verstappen T, Tholen G, Niezink AGH, De Ruysscher DKM, Berbée M.   +15 more
europepmc   +1 more source