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Dosimetric comparison of intensity-modulated proton therapy and proton arc therapy for pediatric ependymoma [PDF]

Acta Oncologica
Background and purpose: Proton Arc Therapy (PAT) is an emerging proton therapy treatment modality with the potential to reduce radiation exposure to healthy tissues compared to conventional Intensity-Modulated Proton Therapy (IMPT) with fewer beams. This
Helge Henjum, Karoline Mo Feten, Erlend Hartvigsen, Kristian S. Ytre-Hauge, Camilla G. Boer, Camilla H. Stokkevåg   +5 more
doaj   +6 more sources

Influence of beam pruning techniques on LET and RBE in proton arc therapy [PDF]

Frontiers in Oncology, 2023
IntroductionProton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk.
Helge Henjum, Johannes Tjelta, Johannes Tjelta, Lars Fredrik Fjæra, Sara Pilskog, Sara Pilskog, Camilla H. Stokkevåg, Camilla H. Stokkevåg, Erlend Lyngholm, Andreas H. Handeland, Andreas H. Handeland, Kristian S. Ytre-Hauge   +11 more
doaj   +8 more sources

Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy [PDF]

Radiation Oncology
Background This study reports the single-institution clinical experience of multifield pencil beam scanning (PBS) intensity-modulated proton therapy (IMPT) and dosimetric comparison to proton arc for uveal melanoma (UM) in a regular PBS gantry room ...
Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis Yu, Qing Chen, Yunjie Yang, Minglei Kang, Huifang Zhai, Milo Vermeulen, Andy Shim, Peter Park, Xuanfeng Ding, Jun Zhou, David H. Abramson, Jasmine H. Francis, Charles B. Simone, Christopher A. Barker, Haibo Lin   +18 more
doaj   +5 more sources

Risk of second primary cancer from proton arc therapy of pediatric brain tumors [PDF]

Physics and Imaging in Radiation Oncology, 2023
Proton arc therapy (PAT) is currently explored for clinical implementation, despite its associated low-dose bath. This study therefore aimed at evaluating the risk of radiation-induced second primary cancer (SPC) for PAT in pediatric brain tumor patients.
Laura Toussaint, Daniel J Indelicato, Ludvig P Muren, Camilla H Stokkevåg   +3 more
doaj   +3 more sources

A novel optimization algorithm for enabling dynamically collimated proton arc therapy [PDF]

Scientific Reports, 2022
The advent of energy-specific collimation in pencil beam scanning (PBS) proton therapy has led to an improved lateral dose conformity for a variety of treatment sites, resulting in better healthy tissue sparing. Arc PBS delivery has also been proposed to
Blake R. Smith, Ryan T. Flynn, Daniel E. Hyer   +2 more
doaj   +4 more sources

Range-compensated pencil beam scanning proton Arc therapy: a feasibility study [PDF]

Communications Engineering
Proton arc therapy is a conceptual treatment technique in proton therapy that delivers a scanned proton pencil beam simultaneously as the gantry is rotated around the patient, exploiting the geometric advantages of a continuous arc with the dosimetric ...
Blake R. Smith, Ryan T. Flynn, Alonso N. Gutiérrez, Daniel E. Hyer   +3 more
doaj   +2 more sources

Proton Arc Therapy vs Interstitial HDR Brachytherapy in Gynecologic Cancer with Parametrial/pelvic Side Wall Extension [PDF]

International Journal of Particle Therapy, 2022
Purpose: To investigate whether volumetric-modulated proton arc therapy (VPAT) plans generate comparable doses to organs at risk (OARs) compared with interstitial high– dose-rate (iHDR) brachytherapy for patients with gynecologic cancer with disease ...
ByongYong Yi, PhD, Sina Mossahebi, PhD, Arezoo Modiri, PhD, Elizabeth M. Nichols, MD, Mariana Guerrero, PhD, Narottam Lamichhane, PhD, Pranshu Mohindra, MD   +6 more
doaj   +2 more sources

Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study [PDF]

Frontiers in Oncology, 2021
PurposeTo integrate dose-averaged linear energy transfer (LETd) into spot-scanning proton arc therapy (SPArc) optimization and to explore its feasibility and potential clinical benefits.MethodsAn open-source proton planning platform (OpenREGGUI) has been
Xiaoqiang Li, Xuanfeng Ding, Weili Zheng, Gang Liu, Gang Liu, Guillaume Janssens, Kevin Souris, Ana M. Barragán-Montero, Di Yan, Craig Stevens, Peyman Kabolizadeh   +10 more
doaj   +2 more sources

Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy [PDF]

Radiation Oncology, 2020
Background This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning proton arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to further reduce radiation dose to ...
Sheng Chang, Gang Liu, Lewei Zhao, Joshua T. Dilworth, Weili Zheng, Saada Jawad, Di Yan, Peter Chen, Craig Stevens, Peyman Kabolizadeh, Xiaoqiang Li, Xuanfeng Ding   +11 more
doaj   +2 more sources

A dosimetric and robustness analysis of proton arc therapy with early energy layer and spot assignment for lung cancer versus conventional intensity modulated proton therapy [PDF]

Acta Oncologica
Background and purpose: Intensity Modulated Proton Therapy (IMPT) faces challenges in lung cancer treatment, like maintaining plan robustness for moving tumors against setup, range errors, and interplay effects. Proton Arc Therapy (PAT) is an alternative
Macarena S. Chocan, Sophie Wuyckens, Damien Dasnoy, Dario Di Perri, Elena Borderias Villarruel, Erik Engwall, John A. Lee, Ana M. Barragan-Montero, Edmond Sterpin   +8 more
doaj   +2 more sources