Results 151 to 160 of about 14,370 (210)

Selective Cell‐Repellent 3D Scaffold Platform for Proton Radiobiology

Advanced NanoBiomed Research, EarlyView.
A selective cell‐repellent 3D scaffold platform is developed to minimize unwanted 2D cell populations surrounding engineered cell microenvironments. The approach is based on the combination of Lipidure coatings with two‐photon polymerized scaffolds and enables specific characterization of glioblastoma cells’ response to proton irradiation.
Novinda S. Pertiwi, Qais Akolawala, Rob van den Akker, Anggraeini Puspitasari‐Kokko, Henri H. Versteeg, Araci M. R. Rondon, Angelo Accardo   +6 more
wiley   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Assessment of intra-fractional and inter-fractional motion in esophageal cancer treated with intensity-modulated proton therapy. [PDF]

BMC Cancer
Fan X, Wang S, Li W, Meng K, Huang W, Yin Y, Dai T.   +6 more
europepmc   +1 more source

New energy layer reduction method for rapid intensity-modulated proton therapy (IMPT) using a ridge filter. [PDF]

Med Phys
Wang A, Zhu YN, Setianegara J, Lin Y, Hamaide V, Pin A, Xiao P, Xie Q, Gao H.   +8 more
europepmc   +1 more source

Proton arc therapy and associated improvements in quality-adjusted life expectancy for head-and-neck cancer patients compared to volumetric modulated arc therapy and intensity-modulated proton therapy. [PDF]

Phys Med Biol
Tattenberg S, Liu P, Mulhem A, Cong X, Harbert E, Hoehr C, Ding X.   +6 more
europepmc   +1 more source

Training and Validating a Knowledge-Based Model for Intensity Modulated Proton Therapy of Prostate and Pelvic Lymph Nodes. [PDF]

Cureus
Anderson P, Xu Y, Bui R, Cyriac J, Kaderka R, Bossart E, Hanson N, Dogan N.   +7 more
europepmc   +1 more source

Evaluation of a non-metallic dual-port expander for intensity modulated proton therapy. [PDF]

J Appl Clin Med Phys
McConnell K, Fellows Z, Kraus J, Acosta M, Panoff J, Pons E, Gutierrez A, Wroe A.   +7 more
europepmc   +1 more source

Intensity-modulated proton therapy for hippocampal-sparing prophylactic cranial irradiation: a planning comparison with photon therapy. [PDF]

BMC Cancer
Yin X, Lin X, Zhang G, Yin Y, Sun T.
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source