Results 131 to 140 of about 96,362 (287)

Accretion regimes in the X-ray pulsar 4U 1901+03

, 2016
The source 4U 1901+03 is a high-mass X-ray pulsar than went into outburst in 2003. Observation performed with the Rossi X-ray Timing Explorer showed spectral and timing variability, including the detection of flares, quasi-periodic oscillations, complex ...
Milonaki, F., Reig, P.
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Method for Predicting the Communication Channel Capacity of Unmanned Aerial Vehicles Based on Telemetry Data

Кібернетика та комп'ютерні технології
The article presents an approach to constructing a mathematical model for predicting the throughput capacity of unmanned aerial vehicle communication channels based on the analysis of SITL telemetry logs.
Svitlana Kashkevych, Nadiia Marchenko, Yurii Dehtiar   +2 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Magnetic resonance imaging (MRI) radiomics in paediatric neuro-oncology: A systematic review of clinical applications, feature interpretation, and biological insights in the characterisation and management of childhood brain tumours

Digital Health
Background Childhood brain tumours, even though rare, present with significant diagnostic and treatment challenges. Radiomics involves feature extraction that is data-driven from standard imaging modalities, such as magnetic resonance imaging (MRI).
Teesta Mukherjee, Omid Pournik, Theodoros N Arvanitis   +2 more
doaj   +1 more source

Mindsets and menses: decoding young women’s attitudes towards menstrual leave – an observational study from South India

BMJ Open
Objective The primary objective of this study is to investigate the perceived need and attitudinal perspectives regarding menstrual leave policies among young women in rural South India.
Neethu George, Rock Britto Dharmaraj, Pavithra Mahendran, Karthikeyan Kulothungan, Tamilarasan Muniyapillai, Thirumalaikondu Subramanian, Abhirami Muthu Ranga Babu, Aakash Arumugam, Sarasmathi Subramanian, Shabhana Shabash Khan, Srinivasan Selvam, Aakash Veeraragavan Suresh Babu   +11 more
doaj   +1 more source