Results 121 to 130 of about 96,362 (287)

Volume Electron Microscopy: Imaging Principles, Computational Advances and Applications in Multi-Scale Biological System

Crystals
Volume electron microscopy (Volume-EM) has transformed structural cell biology by enabling nanometre-resolution imaging across cellular and tissue scales.
Bowen Shi, Yanan Zhu
doaj   +1 more source

Dynamical Properties of Heavy-Ion Collisions from the Photon-Photon Intensity Correlations

, 1993
We consider here the bremsstrahlung emission of photons at low and intermediate energies $ E_{lab}\le 1000 MeV/u$ of the projectile. and derive expressions more general than previous results obtained by Neuhauser which were limited to the case of ...
Bjorken, Cassing, Grosse, L.V. Razumov, Marques, Marques, Metag, Migneco, Neuhauser, Nifenegger, Plümer, R.M. Weiner, Razumov, Srivastava   +13 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Calibration of normalised CES production functions in dynamic models [PDF]

Normalising CES production functions in the calibration of basic dynamic models allows to choose technology parameters in an economically plausible way. When variations in the elasticity of substitution are considered, normalisation is necessary in order
Klump, Rainer, Saam, Marianne
core  

Constraining the fraction of Compton-thick AGN in the Universe by modelling the diffuse X-ray background spectrum

, 2012
This paper investigates what constraints can be placed on the fraction of Compton-thick (CT) AGN in the Universe from the modeling of the spectrum of the diffuse X-ray background (XRB). We present a model for the synthesis of the XRB that uses as input a
Akylas, A., Brightman, M., Georgakakis, A., Georgantopoulos, I., Nandra, K.   +4 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Extracting individual contributions from their mixture: a blind source separation approach, with examples from space and laboratory plasmas

, 2010
Multipoint or multichannel observations in plasmas can frequently be modelled as an instantaneous mixture of contributions (waves, emissions, ...) of different origins.
Amblard, Aubry, Bobin, Brekke, Cardoso, Carey, Comon, Dinklage, Dudok de Wit, Dudok de Wit, Haykin, Hyvärinen, Kim, Kuruoglu, Leach, Lean, Lee, Lee, Lopes Cardozo, Moret, Moussaoui, Nascimento, Pedersen, Shi, Ségui   +24 more
core   +4 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The High Energy Emission of the Crab Nebula from 20 keV to 6 MeV with INTEGRAL

, 2009
The SPI spectrometer aboard the INTEGRAL mission observes regularly the Crab Nebula since 2003. We report on observations distributed over 5.5 years and investigate the variability of the intensity and spectral shape of this remarkable source in the hard
Bartlett, E. Jourdain, J. P. Roques, Jourdain, Ling, Massaro, Owens, Wunderer   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source