Results 101 to 110 of about 16,736 (246)

Carotid plaque dynamic contrast-enhanced magnetic resonance imaging normalised signal intensity reproducibly differs between plaque and vessel wall

ABSTRACT Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables non-invasive characterization of carotid atherosclerotic plaque. Purpose To evaluate the performance and reproducibility of a simplified DCE-
Thomas Readford, Gonzalo J Martínez, Sanjay Patel, Peter L. Kench, Marcelo Andía, Martin Ugander, Nicola Giannotti   +6 more
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Magnetic resonance imaging (MRI) radiomics in paediatric neuro-oncology: A systematic review of clinical applications, feature interpretation, and biological insights in the characterisation and management of childhood brain tumours

Digital Health
Background Childhood brain tumours, even though rare, present with significant diagnostic and treatment challenges. Radiomics involves feature extraction that is data-driven from standard imaging modalities, such as magnetic resonance imaging (MRI).
Teesta Mukherjee, Omid Pournik, Theodoros N Arvanitis   +2 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Evaluating the implementation of a ward-based training programme within an intensive psychiatric care unit using Normalisation Process Theory [PDF]

Background: Strong staff-patient relationships are essential for the provision of high quality care within psychiatric intensive care units. These relationships can be strengthened through staff training interventions, for example, the Safe & Secure programme.
Duffy, Aiden, Goodall, Karen; id_orcid 0000-0002-7832-9098, Carmichael, David, Harper, Sean, Sivyer, Katy, Carnelly, Kathy, Maguire, Tess, Newman-Taylor, Katherine   +7 more
openaire  

Practitioner perspectives on implementing a quality improvement intervention for telephone-based therapy in NHS Talking Therapies: a qualitative process evaluation study

BMC Health Services Research
Background Understanding the factors that shape implementation processes is fundamental to improving outcomes and applicability of interventions. This study reports on part of a process evaluation nested within a cluster randomised controlled trial.
Cintia Faija, Judith Gellatly, Kelly Rushton, Penny Bee, Helen Brooks   +4 more
doaj   +1 more source

Method for Predicting the Communication Channel Capacity of Unmanned Aerial Vehicles Based on Telemetry Data

Кібернетика та комп'ютерні технології
The article presents an approach to constructing a mathematical model for predicting the throughput capacity of unmanned aerial vehicle communication channels based on the analysis of SITL telemetry logs.
Svitlana Kashkevych, Nadiia Marchenko, Yurii Dehtiar   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source