Results 101 to 110 of about 3,925,241 (306)

Tandem mass spectrometry data quality assessment by self-convolution

BMC Bioinformatics, 2007
Background Many algorithms have been developed for deciphering the tandem mass spectrometry (MS) data sets. They can be essentially clustered into two classes.
Tham Wai, Choo Keng
doaj   +1 more source

Implementing palliative care in intensive care units: assessing processes using the normalisation process theory NoMAD instrument

Implementation Science Communications
Abstract Background The importance of palliative care for Intensive Care Unit (ICU) patients/families is known. Little is known about implementing this care in practice, and how to support healthcare professionals in this implementation.
Stephanie A. Meddick-Dyson, Tracy Finch, Jason W. Boland, Mark Pearson, Andy Bradshaw, Fliss E. M. Murtagh   +5 more
openaire   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Normalisation factors

, 2021
Normalisation factors of reactivity profiles for MS2 RNA which has undergone X-ray footprinting in transcript, in virio, post extraction and post reassembly.Normalisation factors are taken as averages over reactivity profiles which have been generated ...
Sam Clark (9249305)
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Evaluating ESG Practices from the Perspective of Transparency and Accountability Through Clustering Analysis and MCDM Methods

Sustainability
This study explores the Environmental, Social, and Governance (ESG) disclosure practices of 31 information technology firms listed on Borsa Istanbul (BIST), with a particular emphasis on transparency and accountability.
Neylan Kaya, Aslıhan Ersoy Bozcuk, Burçin Tutcu, Mustafa Terzioğlu, G. F. Ünal Uyar   +4 more
semanticscholar   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Variable Screening and Rank-Stability Diagnostics for GIS-Based Pre-Transformation Valuation Support in an Istanbul Urban Renewal Area

Land
Prioritising properties for early review in dense urban renewal areas is a spatial multi-criteria decision problem in which physical condition, accessibility, environmental quality, and hazard exposure must be weighed before formal appraisal.
Özge Öztan, Aslı Bozdağ, Ahmet Emin Karkınlı, Mustafa Hüsrevoğlu, Fatih Eren, Tahsin Yomralıoğlu, Ramazan Alper Kuçak, Zeynep Ünal   +7 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Absolute intensity normalisation of powder neutron scattering data

An important property of neutron scattering data is that they can be normalised in absolute intensity units. In practice, however, such normalisation is often not performed, since it can be time-consuming and subject to systematic uncertainties.
Paddison, Joseph A. M.
core   +1 more source